Published today in Nature Genetics research studying the DNA of around 800,000 women found >1000 small changes in DNA that influence the age of first menstrual period The study was conducted by researchers from King's College, Cambridge Newnham College Cambridge University buff.ly/4cAZSj8

I am particularly intrigued by the statistically significant interaction between polygenic score and rare deleterious variants in ZNF483. The effect of polygenic risk on age at menarche is "abolished" by rare variants in ZNF483. The gene encodes a transcription factor and many