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Extremely simple biophysical models do surprisingly good genetic prediction in sequence spaces >10^10, suggesting that vogue deep learning models may be unnecessarily complex. New work + scientific debut for Aina Martí-Aranda w/ cristina hidalgo-carcedo & Ben Lehner biorxiv.org/content/10.110…

I was busy, and it was not a quick question

summer for scientists in the UK #phdlife #lablife #cellmates #thecellmatescartoons

The genetic architecture of protein stability by Andre Faure @ajfaure.bsky.social Aina Martí cristina hidalgo-carcedo @ToniBeltran13 Joern Schmiedel nature.com/articles/s4158… Centre for Genomic Regulation (CRG) Wellcome Sanger Institute ALLOX

Check out our latest #biochem episode with Isabelle Zane all about genes & proteins, deep mutational scanning, and how to investigate protein structure & function🧬🧫🥼👩‍🔬🧪🔦 spotifyanchor-web.app.link/e/bTQvJX0hoNb

“We’re aiming to submit the paper in 6 months” but we also said that 6 months ago… we said that a year ago too… #phdlife #lablife #cellmates #thecellmatescartoons #sciart

With more variations of a small protein than atoms in the universe, how can scientists possibly predict mutation effects? 🌌 With simple maths, finds new research This could speed up our understanding of diseases and drug design sanger.ac.uk/news_item/prot…

The evolution of allostery in a protein family. New preprint from the brilliant Aina Martí. Seven complete allosteric maps. biorxiv.org/content/10.110…