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HHMI Investigators Cigall Kadoch & brangwynnelab discovered that seemingly structureless regions of proteins, known as intrinsically disordered regions, have unique amino acid sequences that impact chromatin remodeling & influence how diseases develop. ⬇️ hhmi.news/3Qm74Hv

New research from Dana-Farber researcher Dr. Cigall Kadoch reveals a key role for intrinsically disordered proteins that are implicated in a wide range of human diseases, from #cancer to #neurodegeneration. Read more: shorturl.at/szDMP Abstract: shorturl.at/isGMV

Thank you, HHMI for featuring our new work on intrinsically disordered proteins and their specificities in the context of #chromatin remodeling complexes! Kadoch Lab Ajinkya Patil Amy Strom brangwynnelab @PappulabWashU

Post Ph.D. weekends!

Exciting new study by Mark Foundation Emerging Leader awardee Cigall Kadoch and co-author Mark Foundation/Life Sciences Research Foundation Fellow Amy Strom - Congratulations! We were fortunate to preview this work last week during Cigall’s #MarkSymposium presentation. Cigall Kadoch Kadoch Lab Amy Strom

Disordered protein regions partner up the cBAF remodeler for a chromatin dance dlvr.it/SySPl3

Thank you Molecular Cell for highlighting our recent work at Kadoch Lab brangwynnelab!

Thank you Molecular Cell for this terrific #Spotlight piece written about our new work published last month in Cell Cell Press! Congrats again to Ajinkya Patil Amy Strom brangwynnelab @PappulabWashU Kadoch Lab and all coauthors!

So well deserved. Congratulations Cigall Kadoch! So proud of you!! 😃

Looking for great postdocs to work on cool RNA/Protein/Condensate projects spanning multiple labs! ...new Chan Zuckerberg Initiative-funded program with Arjun Raj Jerelle A Joseph #KlingeLab #Cristealab & Liu Lab (Dr. Kathy F. Liu) More info here: docs.google.com/forms/d/14Fvws… (please apply & also help spread the word!)

Dr. Cigall Kadoch (Cigall Kadoch) of Dana-Farber, Harvard Medical School, @hhminews, and Broad Institute has been named a recipient of this year’s Paul Marks Prize for #CancerResearch. Congratulations Dr. Kadoch! We can't wait to see your future work. 🎉 Read more: bit.ly/3R8gmrg

Yay! Go Amy Strom!

For readers interested in targeted protein degradation, here's a comprehensive review of the field from some of the pioneers bit.ly/3uveksC rdcu.be/dyrXn

Congratulations, Dr. Ajinkya Patil on your official graduation from Harvard Medical School and an honor to hood you and meet your family!! So many amazing achievements in your PhD! And thrilled to watch past Kadoch Lab member Dr. John Pulice also walk across the stage! Congratulations!!!

Congratulations to our Kadoch Lab graduate student, now officially Dr. Ajinkya Patil Ajinkya Patil on his graduation from The PhD Program in Virology at HMS Harvard Medical School !! And to past computational biologist and BBS at Harvard student Dr. John Pulice John Pulice !!!

Thank you, Nature Reviews Drug Discovery for the opportunity to discuss new mechanistic insights and small molecule agents targeting chromatin remodeling complexes- was a pleasure working with Asher Mullard on this interview! Kadoch Lab Foghorn Therapeutics #cancer #drugdiscovery #chromatin

Awesome!! Looks like the lab is having a fantastic summer!

Thrilled to see this out! Congratulations Amy Strom yoonji kim brangwynnelab!!

Force of nature is correct!! Congratulations Cigall Kadoch! So proud!!

Disordered protein regions are commonly mutated or dysregulated in disease, but considered undruggable. How can we effectively target them with small molecule therapeutics? These experts have some ideas: