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There’s been speculation about a parallel nascent protein degradation track to NMD ever since Takahashi et al (RNA 2008) reported a Upf1 E3 ligase activity. Inglis et al show there’s much more to this cool new story. biorxiv.org/content/10.110…

January mornings can be really special around here…

An extraordinary discovery: the wreck of Endurance, Shackleton’s ship that sunk in the Antarctic in 1915, has been discovered at the bottom of the Weddell Sea. Photos taken by the Endurance22 Expedition reveal a remarkably intact relic. See: endurance22.org/endurance-is-f…

Gotta love this photo. Can't wait for all the alternative explanations for the wreckage.....NASA’s Mars Helicopter Spots Gear That Helped Perseverance Rover Land jpl.nasa.gov/news/nasas-mar… via NASA JPL

See the FEBS Journal for an "early view" of our new review on mRNA decapping: febs.onlinelibrary.wiley.com/toc/17424658/2… As always, a pleasure and a learning experience collaborating on this project with my insightful colleague Feng He.

Selective profiling of Upf1-associated ribosomes, two distinct Upf1:80S complexes, ATPase-deficient interferes with normal translation termination, and more. Our longest NMD project now at RNA Advance Online: rnajournal.cshlp.org/content/early/…

via The New York Times. They certainly don’t make ‘em like this anymore….. nytimes.com/2022/10/28/art…

Our latest, just out in RNA: "Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance" (rnajournal.cshlp.org/content/28/12/…)--Kudos to Robin Ganesan and Kotcha Mangkalaphiban!

Remarkable personal story from Sanford Simon Rockefeller University about turning his research to studying a rare cancer his daughter was diagnosed with. nature.com/articles/s4156…

PABPC regulates multiple cytoplasmic steps in gene expression, an inescapable conclusion of our latest work: Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay biorxiv.org/content/10.110…

Congrats to DR(!) Kotcha Mangkalaphiban for her fabulous PhD thesis defense today. Her thesis (“mRNA sequence features determine the efficiency of translation termination”) has already led to two papers and two more are in the works. She’s definitely a rising star!

Our state-of-the-art review on "Eukaryotic mRNA decapping factors: molecular mechanisms and activity" is finally available as an open access paper in the print version of The FEBS Journal. See: buff.ly/3snDwA7

Just out in Nature Communications. Great finish to Kotcha's thesis work and extremely productive collaboration with Bedwell lab at UAB! We define cis-acting sequences regulating translation termination & accurately predict readthrough efficiency of multiple CFTR nonsense alleles.

Our yeast lab turned to mice for a change: nonsense suppression in a complex neurofibromatosis mouse model (doi.org/10.1016/j.expn…). Congrats to Chan Wu for leading the project and many thanks to our collaborators, Salman Shazeeb and the Gounis lab!

Just set up another home. Hope to see you there: Allan Jacobson.bsky.social