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Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 Nature Medicine

Large-scale discovery, analysis, and design of protein energy landscapes - This study introduces a multiplexed hydrogen-deuterium exchange mass spectrometry (mHDX-MS) technique to analyze the energy landscapes of thousands of protein domains in parallel. This approach reveals

Small proteins can be more complex than they look! We know proteins fluctuate between different conformations- but how much? How does it vary protein to protein? Can highly stable domains have low stability segments? Állan Ferrari experimentally tested >5,000 domains to find out!

I never publicly said it in my thread of #NeurIPS 2024 coverage on the other place, but this was probably my FAVORITE talk of MLSB workshop in Vancouver! Gabe’s team always has innovative & creative HTS methods to learn more about protein structure & biophysics, give this a read!

Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with Martin Pacesa, Zhidian Zhang , Bruno E. Correia, and Sergey Ovchinnikov. 🧬 Code will be released in a couple weeks