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I'm looking for postdocs to join our team to work on the structural biology of LRRK2. #CryoEM #LRRK2 #parkinson jobrxiv.org/job/leschziner…

Thanks to Aligning Science Across Parkinson’s for supporting our work on #LRRK2 and Parkinson’s Disease with @SamReck_Peterson, Elizabeth Villa, Stefan Knapp and Florian Stengel! #cryoEM #Parkinsons parkinsonsroadmap.org/research-netwo…

UC San Diego Scientists to Explore New Frontiers in Parkinson’s Disease Research with $7.2M Grant ucsdnews.ucsd.edu/feature/uc-san… Samara Reck-Peterson Andres Leschziner Elizabeth Villa UC San Diego School of Medicine Aligning Science Across Parkinson’s michaeljfox.org

Thrilled to announce I will be joining BioE and Genetics at @Stanfordmed and Stanford Engineering as an Assistant Professor in 2022. My lab will be part of Stanford Bio-X and Chan Zuckerberg Biohub Network and I look forward to joining such incredible communities of colleagues, trainees and new friends! 1/

The Leschziner lab at UCSD has 2 open postdoctoral positions to study the structural basis of Parkinson’s Disease and intracellular transport using cryo-EM. Come join our vibrant cryo-EM community! andres-leschziner.squarespace.com/positions

We are looking for a postdoc with expertise in biochemistry and biophysics to join us to study the mechanisms of intracellular transport: reck-peterson.ucsd.edu/positions-avai…. Come join our collaborative environment! UC San Diego School of Medicine UCSD BioSciences #HHMIInvestigators Aligning Science Across Parkinson’s

🟢 My lab is opening in May! 🎊I am #recruiting at all levels to build a diverse group. Join us in discovering new biology and engineering next-gen biotechnology! #synbio #immunology #cancer #microbes Please reach out and RT to help me spread the word! 👉 hl-lab.org

Check out Kavita Rangan’s work in this new preprint from our lab! We show that wild squid rapidly employ RNA recoding to generate unique kinesin motor variants in different ocean temperatures. doi.org/10.1101/2022.0… 1/

Kinesin variants generated in cold seawater display enhanced motile properties in single-molecule experiments conducted in the cold. 2/

We also show that cephalopod recoding sites can be used as a guide to gain mechanistic insight into the function of conserved non-cephalopod proteins. 3/3

Excited to share this wonderful collaborative story on how Lis1 helps relieve dynein auto-inhibition. Loved working with Andres Leschziner and the extraordinary women that are Janice Reimer, Aga Kendrick and Samara Reck-Peterson biorxiv.org/content/10.110…

New preprint! Parkinson’s Disease-linked LRRK2 and non-PD-linked LRRK1 have distinct mechanisms for regulating their kinase activity. Awesome UCSD BioSciences collaboration with Andres Leschziner and Matt Daugherty supported by Aligning Science Across Parkinson’s. biorxiv.org/content/10.110…. 1/2

Our CryoEM structures show that LRRK1 has two levels of autoinhibition: 1) in trans via dimerization and 2) a phosphorylation regulated in cis mechanism. Our evolutionary analysis of LRRK proteins reveals when specific structural features arose during metazoan evolution 2/2

Looking for a motivated and intellectually curious Research Assistant to join our lab at UCSD (andres-leschziner.squarespace.com/positions) for post-baccalaureate studies. We have a culture of providing excellent training and placing people in PhD and MD/PhD programs. employment.ucsd.edu/research-assoc…

1/ Our newest work on Lis1 with the Andres Leschziner lab and co-first authors Eva Karasmanis, @janicereimer3, and @aga_kendrick suggests a mechanism for Lis1’s relief of dynein autoinhibition: nature.com/articles/s4159…. Janet Iwasa’s animation of our model:

We report the first #cryoEM structures of #LRRK2 bound to type-1 and type-2 kinase inhibitors. Great team effort to advance Parkinson’s Disease therapeutics research! #StefanKnapp __as_n_ Kinas_s Marta Amalia Villagran-suarez Verena Dederer Aligning Science Across Parkinson’s biorxiv.org/content/10.110…

Very happy to see our study on cofilactin filaments inside the microtubule lumen now published in EMBO Reports: embopress.org/doi/full/10.15…

The more European part of our ASAP Team! Thank you Aligning Science Across Parkinson’s #CRNLondon2023 Andres Leschziner __as_n_ Kinas_s

Awesome collaboration with outstanding structural work by @janicereimer3 (as usual). Thanks to the whole team!

We are looking for motivated people to join our group as #postdocs to work on the structural biology of #Parkinsons. We’re a #cryoEM lab focusing on #LRRK2. Please repost! andres-leschziner.squarespace.com