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Some great work led by a rockstar graduate student at WashU! Worth a read for those interested in alcohol use and use disorder trajectories and genetics. #addiction

Our article exploring the neurobiological correlates of prenatal cannabis exposure is now out! "Prenatal cannabis exposure, the brain, and psychopathology during early adolescence" rdcu.be/dMJqH

📢 New study led by Christal N. Davis, and colleagues reveals that candidate genes from an FDA-approved algorithm fail to predict opioid use disorder (OUD) risk in over 450,000 veterans. This study raises concerns about the clinical utility of the algorithm in predicting OUD. 🚨

Hi Everyone - the substance use disorders working group (PGC-SUD) will be taking over the PGC Consortium account for the next two weeks. Follow along as we share exciting updates and papers, highlight recent news, and spotlight important progress in the field overall. Join us!

In the largest study of problematic alcohol use (PAU) to date led by Hang Zhou of Yale Psychiatry, researchers identified >100 risk variants across multiple ancestral populations and found significant genetic correlations with PAU in non-European individuals. bit.ly/3t6wDnj

A study of cannabis use disorder (CanUD) led by Dan Levey of Yale Psychiatry identified risk variants in each of the studied ancestry groups, found distinctions between CanUD and cannabis use, and helped place cannabis traits among other related health outcomes go.nature.com/49Nj1Ou

A study led by AlexanderSHatoum found evidence for a generalized addiction risk factor that identified 19 risk variants including variants involved in dopamine regulation, along with many substance-specific variants involving drug metabolism and receptors. go.nature.com/3N3M2v7

A recent preprint led by Christal Davis and Henry Kranzler found no evidence to support the clinical utility of a set of 15 genetic variants that are the basis of an FDA-approved genetic screener for identifying individuals at risk for opioid use disorder. bit.ly/3TPbBDT

Congratulations to PGC-SUD researcher Alex P. Miller on his recently awarded K01 from NIAAA News. Alex will examine neurogenetic influences linking impulsivity and alcohol use disorder progression across development at IU School of Medicine and his work with PGC Consortium and COGA.

In a PGC Consortium special issue of Psychological Medicine (Cambridge UP - Psychology & Psychiatry), PGC-SUD researchers @e_covey_johnson and Joseph D. Deak, PhD provide a review covering the genetics of substance use disorders: bit.ly/3oMZM03

A study led by @e_covey_johnson examined genetic relationships among schizophrenia, cannabis use, and cigarette smoking. The study identified 327 pleiotropic variants (150 novel) and provided insight into shared genetic factors and potential causal links. bit.ly/3TNcPiL

📝📝Pop Quiz: One of the largest effect sizes of any SNP on a polygenic trait influences behavior (#2 after hair color), can you guess the trait and gene? 📝📝 (Hint: This is the PGC substance use disorder takeover)

SUDs are heterogenous concepts. To understand genetic effects on SUDs, we need to contextualize genetic effects on behavior, brain, and development. In this review, Bogdan and Colleagues develop a framework for contextualizing discoveries in SUDs. bit.ly/4dtGy7x

Excited to share that this manuscript has now been published Nature Mental Health! nature.com/articles/s4422…

I’m proud to have co-signed this letter of concern, published today in The Lancet Psychiatry, alongside 140 international experts in psychiatric genetics. Innovation should benefit patients without causing greater harm. #WCPG2024 AlexanderSHatoum thelancet.com/journals/lanps…

Hello all! I've made the move over to BlueSky, Find me AlexanderSHatoum.bsky.social. I'll be deleing this account in the next week.