This weekend the TYP lab had several relay teams in the Maine Marathon to support the Josephine and John Marr Alzheimer's Research Fund through Brigham and Women's Hospital! We are so thankful for everyone who supported us and for the Marr family for their generosity!

Our talented grad student, Alex Lish, gave an exceptional talk on how CLU modulates astrocyte reactivity & microglia-dependent changes to synaptic density in AD at the Neurogenerative Diseases: Biology & Therapeutics Meeting #glia #cshlmeetings #cshldegen #Alzheimers

Happy holidays from the TYP lab! We had a blast celebrating the season on Friday with our annual holiday party!

New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort. You can find it here: onlinelibrary.wiley.com/doi/10.1002/gl…

Congratulations to the newly minted PhD Alex Lish on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!

New online! Multi-ancestry GWAS identifies 16 novel Alzheimer disease risk loci bit.ly/4iaJCrx

Online now: CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density dlvr.it/TKT36h

Thrilled to share my first first-author paper is out in Neuron! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here sciencedirect.com/science/articl…

New TYP lab paper out today in Neuron led by PhD student Alex Lish! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! cell.com/neuron/abstrac…

Well deserved!! We are super lucky to have an amazingly dedicated mentor. Congratulations Tracy!

Shoutout to our lab at the ROSMAP meeting! Thanks David and the great team at Rush Alzheimer's Disease Center for a great meeting! 🎉 Sarah Heuer, PhD gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆 🧠 Gizem Terzioğlu crushed it with her presentation on SHIP1 & the inflammasome!

Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬 Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠 🔗 gbm-online.de/de/studium-kar…

🎓Congratulations to our incredible grads! 🎉 Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂 We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 Alex Lish

We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures dlvr.it/TL90F2

Excited to share that our paper describing the establishment of our iPSC-derived triculture model is finally out in Cell Reports! Using this system, we show how the co-culture environment shapes cell responses, with a particular focus on microglia! cell.com/cell-reports/f…

🧠 New study in Brain, led by graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13 academic.oup.com/brain/advance-…

My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and/or retweet!

The best of luck to Alex Lish on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!

actaneurocomms.biomedcentral.com/articles/10.11…