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Online Now: TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma dlvr.it/S4hKVy

Ewing #sarcoma, an aggressive bone tumor, is difficult to target therapeutically. This study from the Stegmaier Lab Dana-Farber/Boston Children's combined several concepts in molecular #oncology to identify new targets. Check out the paper in Cancer Cell. ms.spr.ly/6010nqzD2

A new target for #Ewing sarcoma? Clever detective work by Alex Seong Stegmaier Lab finds that Ewing tumors depend on TRIM8, which degrades a fusion protein called EWS/FLI. Without TRIM8, too much EWS/FLI builds up, causing cell death. Check it out: ms.spr.ly/6013nqz1F

Although we didn’t get the cover, I’m happy to share the art depicting our finding of the “Goldilocks Principle” of fusion oncoprotein.

An in vivo #CRISPR screening platform for prioritizing therapeutic targets in acute myeloid #leukemia Stegmaier Lab Dana-Farber Broad Institute #leusm cancerdiscovery.aacrjournals.org/content/early/…

Out today in Cancer Discovery from postdoc Shan Lin. "An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML." Congratulations Shan! Dana-Farber/Boston Children's

Amazing opportunity with a fabulous mentor!

#ChildhoodCancer stands no chance on this #dfci research floor - the Stegmaier Lab volker hovestadt and Filbin labs work together to find new cures. Dana-Farber/Boston Children's Dana-Farber Boston Children's #ChildhoodCancerAwarenessMonth

The Nabet lab Fred Hutch Cancer Center is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in developing targeted protein degradation technologies and advancing proximity-induced therapeutic strategies? Please RT & apply here: careers-fhcrc.icims.com/jobs/20699/pos…

The Nabet lab website is live!! Grateful to the Fred Hutch Cancer Center team for help in development. We're building a highly collaborative/supportive lab and are hiring at all levels for multiple funded positions. Contact me directly if interested! research.fredhutch.org/nabet/en.html

Wordle 206 2/6 ⬛⬛🟩🟩🟩 🟩🟩🟩🟩🟩 !!!!!

Wordle 214 2/6 ⬛⬛⬛⬛⬛ 🟩🟩🟩🟩🟩 ?!!!?!?

The Sweet-Cordero lab is hiring a postdoc interested in studying sarcoma metastasis using cutting edge single cell omics and lineage tracing in unique patient-derived models and GEMs. Highly collaborative environment at UCSF. Please RT

Just finished my last day in the Stegmaier lab. Forever grateful for the amazing 5 years of doing exciting science. Thank you Kim and all of the past/present lab members Stegmaier Lab. Excited for my next adventure..!!

We are hiring!! Searching for a motivated wet-lab staff scientist and computational scientist to lead cutting edge #SingleCellMultiomics and #SpatialTranscriptomics in childhood brain tumors, as well as #TumorCellShapeShifting projects. Please RT and DM if interested. 🥳

The Nabet lab Fred Hutch Cancer Center is hiring! We are seeking a curious and highly motivated Research Technician to join our growing team and have exciting projects aimed at advancing new targeted protein degradation technologies. Please RT and apply here: careers-fhcrc.icims.com/jobs/21814/res…

We'll be opening lab doors in May and are recruiting a research technician with a start in May or June. If you are interested in studying pediatric cancer please reach out or apply. careers.purdue.edu/job-invite/302… Purdue Borch MCMP Purdue Institute for Cancer Research Purdue Pharmacy

Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, Saurav Kumar and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC3S7Zk9Z…

Kimberly Stegmaier, MD, has been named as Pediatric Oncology Chair. She will also serve as Associate Chief of Division of Hematology/Oncology at Boston Children’s Hospital. Please join us in congratulating her on this achievement. Read more: bit.ly/3EK9Nat