Intriguing report by the Melody Campbell lab using high-resolution EM structures and Sherlock Holmes style evolutionary sequence mapping to posit that the integrins αEβ7 and α4β7 may have indeed borrowed the A/I-domain motif from collagens #integrin biorxiv.org/content/10.110…

Ligands are well-known integrin activators. Here, a new publication describes the design of novel, ligand-site binding integrin activators for integrin α4β1 as a modality for targeting integrins with agonists. doi.org/10.1021%2Facs.… #integrin #activator #agonists #therapeutics

Disruption of integrin heterodimer stability via the beta-propeller provides another approach for developing integrin therapeutics. This manuscript reports on a CRISPR-based screen to identify αVβ5 integrin inhibitors. nature.com/articles/s4159… #integrin #antagonists #therapeutics

Computational drug development for membrane protein targets go.nature.com/3OQW4Rw

Incredible nano-scale insights into integrin signaling dynamics by Jain et al. Integrins assemble into 'hubs' with other adhesome proteins to modulate external stimuli. #integrin #signaling doi.org/10.1101/2024.0…

Integrins have context-dependent roles in cancer, opening new targeting avenues. Recent work analyzes the Cancer Genome Atlas (TCGA) database, focusing on how integrins correlate with different cancer types and clinical outcomes. doi.org/10.1101/2023.1… #integrin #cancer

New research highlight: using transgenic fruit flies to mimic the human kidney and validate pathogenic collagen mutations found in human patients. Gene-level precision medicine may soon be the norm! doi.org/10.1101/2024.0… #integrin #Alport

Slowly inching closer towards the targeted computational design of antibody therapeutics with this work by the Baker Lab! doi.org/10.1101/2024.0…

🧬DNA-based molecular tension probes used to measure single integrin force dynamics! Incredible tools like these advance our understanding of physical cell mechanics. #integrin doi.org/10.1101/2024.0…

New research by the Kagan Lab on #Myddosomes reveals dynamic hubs of TLR signaling driving inflammation. Our CD11b agonist targets these pathways, offering a precise and effective anti-inflammatory solution. doi.org/10.1038/s41586… #Immunotherapy #Inflammation #Integrin

Super excited to share results of a multi year effort of our superstar team that is developing novel, oral treatments for #lupus #nephritis. Reprogramming #innate #immune-system reduces #suPAR, protects #kidney & produces #therapeutic benefit in model systems. 🚀 UTMB Health

Exciting news from the Vineet Gupta Lab! Their latest work reveals that Allosite's own CD11b agonist ONT01 reduces kidney damage and systemic inflammation in lupus nephritis models. This therapy could be the game-changer in this kidney disease.💊🔬#Lupus doi.org/10.1101/2024.0…

Congratulations to Dimerix for developing new treatments for #GlomerularDiseases #FSGS by targeting #Innate #ImmuneCell #infiltration in the kidney as a differentiated therapeutic strategy. 🚀🎊

New findings in NEJM. Obinutuzumab, targeting CD20, shows Renal Response in 46.4% #LupusNephritis patients at week 76! Novel strategies targeting #ImmuneCells show great promise! 👏⚡️ nejm.org/do/10.1056/NEJ…

New data suggesting unexpected #AdverseEvents #LICATS associated with #CD19 #CAR-Ts in #SLE and #LupusNephritis within days of infusion, including transient, increased #proteinuria. thelancet.com/journals/lanrh…

Huge congratulations to Rafael Kramann, MD PhD and Team Sequantrix on this Pharma partnership. Outstanding news for translating AI based #DrugDevelopment in #Fibrosis and other #kidneydiseases. Moving the field forward. 👏👏👏

What an accomplishment!!! #Clinical #translation of beautiful #fundamental #discoveries and #insights from lab of Vishal Patel UT Southwestern Medical Center 🚀 Mechanism based Medicines for high unmet need in #ADPKD. Congratulations to Novartis and Regulus UTMB Health UTMBinnovations

High dimensional imaging shows significant infiltration of #inflammatory #myeloid cells in #kidneys of #LupusNephritis patients, further establishing them as a key population to target for #nextgen #therapeutics. Vineet Gupta Resolution of in situ inflammation in human lupus