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Check out new preprint from the Andreas Pfenning lab CPCB. Excited to share work! Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology biorxiv.org/content/10.110…

Look, a Lawler who publishes more than once a year! 😉 Awesome work

Grateful to work on this project alongside outstanding CMU faculty Andreas Pfenning Aryn Gittis, staff, and students Michael Kleyman 🇺🇦!

Exciting preprint fresh out of the Andreas Pfenning lab! Predicting lineage-specific differences in open chromatin across dozens of mammalian genomes biorxiv.org/content/10.110…

Check out my SfN Journals paper introducing cSNAIL, a virus-based technology for neuron-subtype isolation. Really excited to share! jneurosci.org/content/40/50/…

My (non-scientist) sister Emily Lawler and friends actually read my recent publication, took notes, and organized a Q&A with me! How fun and sweet is that?! My heart is so full :)

Ghost’s point color changes dramatically. TIL this is temperature sensitive albinism caused by a pc mutation in the Tyrosinase gene. At high temps, the mutant enzyme is misfolded, resulting in no pigment production. Cold ears = black ears!

Very happy to share our new preprint and the heart of my thesis work. Speed up sequence engineering & isolate neuron subtypes from WT mice using SNAIL! biorxiv.org/content/10.110… Easwaran Ramamurthy Andreas Pfenning

In the course of reporting this story, I sat on the Capitol steps for ten minutes waiting for a source. In that time, a state representative sexually harassed a woman walking into the capitol. That's exactly how prevalent this is. That's exactly how shamelessly this happens.🧵

Ever wanted to intersect cell types, epigenomics, ML, human genetics, and addiction together? Check out new publication: doi.org/10.1523/JNEURO… Thanks to much work from Chai and coauthors Alyssa Lawler Andreas Pfenning morgan wirthlin Easwaran Ramamurthy Michael Kleyman 🇺🇦

New paper introducing SNAIL! 🐌 elifesciences.org/articles/69571 We learn the DNA sequence composition of cell type-specific enhancers and turn our findings into new AAV tools. Many great coauthors including Easwaran Ramamurthy Andreas Pfenning @BaDoiPhan.bsky.social morgan wirthlin @ByrneLabScience William Stauffer

#SfN22 See you this morning (Monday) at poster YY8 for an exploration into schizophrenia risk gene Xpo7! First conference presentation as a postdoc! 🙂🧠

Look what new method to unlock human genetic variants in vivo! Great work from the Andreas Pfenning lab gavia brown Alyssa Lawler Easwaran Ramamurthy morgan wirthlin An in vivo massively parallel platform for deciphering tissue-specific regulatory function biorxiv.org/content/10.110…

Excited to release our cell type atlas of the adult mouse brain! Here’s our portal: braincelldata.org And preprint: biorxiv.org/content/10.110… We find minimal marker sets for all cell types, explore activity-regulated genes, and perform analyses of heritability enrichment.

All single cell assays can now be spatial. Slide tags is simple, reliable single cell with hi-res spatial positioning.  A truly outstanding scientific team: Fei Chen Lab, @andyrusss, Jackson Weir, Naeem Nadaf. biorxiv.org/content/10.110…

The ZoonomiaProject’s sequencing of more than 240 mammal genomes is paving new roads for understanding mammalian diversity and evolution and ourselves. Learn more in a new special issue of Science: scim.ag/2oO #Zoonomia

Today's Science Magazine is an amazing celebration of mammalian evolution with the Zoonomia Project! Grateful for the opportunity to contribute our work on enhancer activity and phenotype evolution from Andreas Pfenning lab science.org/doi/10.1126/sc…

Researchers in Science have used #MachineLearning to identify regions of the genome associated with brain size. scim.ag/2sy #Zoonomia