Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A dlvr.it/THqmvc

Exciting results! Using AID-Degron system, Dr. Yimeng Zhu found that Ku suppresses RNA-mediated innate immunity to accommodate Alu-expansion in primates - solving the misery of Ku essentiality in human cells! Thank@chaolinzhang⁩ biorxiv.org/content/10.110…

Proteogenomic analysis of evolved aneuploid cell lines & primary tumors reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer – including increased expression of DNA replication and repair factors Zuzana Storchova and coworkers embopress.org/doi/full/10.10…

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage. doi.org/10.1101/2025.0…

Want to know more about what lysosomal proteases do outside the lysosomal compartment in cancer cells? Check this out: jeccr.biomedcentral.com/articles/10.11…. Glad to be the senior author of this amazing collaborative effort by RVDuranLAB Pablo Huertas' Lab and GMB-lab

Review: Hyrien et al. discuss the nature of the initiation sites of DNA replication, amalgamating findings from various advanced DNA replication mapping techniques in order to build a more cohesive model of DNA replication initiation. Learn more here: ➡️ tinyurl.com/gd352227

me staring at my reflection in the hood because i forgot what step of the protocol i was on

POSTDOC position available in my group Cabimer Universidad de Sevilla . Please spread the word! Contact: [email protected]

It's out! nature.com/articles/s4158… Structure of the two RAD52 rings forming a spool-like structure at replication fork, rearranging and protecting the fork. Tour-de-force work by Masa Honda and Ali Razzaghi and wonderful (as usual) collaboration with Pietro Pichierri 🇮🇹🇪🇺 @[email protected] 's lab.

Our last work on triple negative breast cancer stem cells now in BiorXiv!! Let's hope for a smooth reviewing process!! :) Marco Saponaro Davies Lab - CH3 Rob Clarke Artios Breast Cancer Now biorxiv.org/cgi/content/sh…

Lab meeting!! 😁

Yesterday was a busy day, when Amador Romero Franco successfully defended his PhD. The end of an era at the lab. Congrats to Amador for a great work. And thanks to the committee for a delightful discussion. Andrés Aguilera Crisanto Gutierrez Barbara Pernaute Antonia Tomas Loba and Emi Herrera

Exciting update! The final version of our paper, "DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models," is now live! authors.elsevier.com/c/1lMN0_Zgudmb…

Our work is already online!

Just the fact that these guys posted a preprint formatted to the blueprint of a 'very famous' editorial is wild 🔴🔴🔴🔴

Excited to share my first PhD paper published in Nucleic Acids Res! This project was led by amazing supervisor Belén Gómez González in Genome Instability & Cancer Lab - SEVILLE. Thanks to all colaborators of Luis Blanco Dávila and John Diffley teams. I hope you like it! Now online here 👇🏼 academic.oup.com/nar/article/53…

Blood pressure, heart rate, and biomarkers Changes in blood pressure, heart rate, and biomarkers did not significantly differ between diets, except triglycerides were significantly lower on the MPF diet, and LDL-C was significantly lower on the UPF diet. 10/

Not only do catnip and silver vine hold a special place in felines’ hearts, but the intoxicating chemicals in these plants also protect cats from mosquito bites, according to Science Advances research from 2021. Learn more on #InternationalCatDay: scim.ag/4fxxO2W

🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. biorxiv.org/content/10.110…