Registration for the 24th Biennial Meeting of the International Society for Developmental Neuroscience is open! Submit abstracts by April 9 ,2022 #DevelopmentalNeuroscience ISDN 2024 Conference

Happy to share our recent paper published in Science Advances Science Advances The mechanisms of astrocyte increase during evolution, and its role in cortical folding. Localized astrogenesis regulates gyrification of the cerebral cortex science.org/doi/10.1126/sc…

A timely meeting ⏰ #EMBODevTempo embl.org/about/info/cou…

Submitted my abstract for the #CSHLglia meeting 2022 to represent Martin-Villalba Lab Cold Spring Harbor Laboratory! So excited to meet the community and share/discuss the results of my PhD project 👨🏽‍🔬

After a couple of great years at Mainz University, I recently returned to DKFZ to team up again with Prof. Dr. Frank Lyko and the fantastic scientists of my beloved DKFZ Epigenetics. I am really very happy to be back! See you in Heidelberg from now on for more & better science🧬!

We're excited to share our latest preprint where we use #singlecell #multiomics to show that stemness is encoded in the methylome of neural #stemcells (NSC) in the adult #brain 🐁🧠 #epigenetics #neuroscience #biorxiv_neursci 👉doi.org/10.1101/2022.0… 🧵1/9

Congrats to the Vorholt Microbiology_ETH and @BartDeplancke for their landmark paper on Live-seq, a method for recording the transcriptome from single cells without killing them! ETH news article: ethz.ch/en/news-and-ev… Paper: rdcu.be/cTPLe

It's time we ban assault weapons so our kids learn to read and write in schools instead of learning to duck and cover.

Drei ERC Synergy Grants für Wissenschaftler der Universität Heidelberg – Europäischer Forschungsrat vergibt hochdotierte Förderungen für komplexe Vorhaben in der Forschung uni-heidelberg.de/de/newsroom/dr…

Here it is: our #inception paper Development „De novo PAM generation to reach initially inaccessible target sites for base editing“ by Kaisa Pakari & Thomas Thumberger We use 2 guides & 2 editors to edit distant nucleotides with NGG base-editors journals.biologists.com/dev/article-ab… #medaka #DNA

A huge thanks to everyone who made this study possible: my mentor Irv Weissman, the lab's brain team (Rahul Rahul Sinha, Nobuko, Joy, Anna et al.), as well as Chan Zuckerberg Biohub Network and Stanford MSTP for their support!

Those of us who have survived in academia long enough have an obligation to make things better for the next generation. One concrete way to do that is to support grad students and postdocs in thinking independently and encouraging them to search for new scientific questions.

I have gathered up a bunch of published #SingleCell datasets from Martin-Villalba Lab and made this thing: a290-data.dkfz.de Nearly 27000 subventricular zone cells from three different publications available for exploration!

The reality of doing science is that most of the time you’re really just waiting for something unexpected to happen; something that doesn’t make sense or a wild new idea. When that happens, it’s up to you to change course and go for it, or let the hard-earned opportunity pass by.

Excited to share our new work on direct protein-based genome editing in primary cells. We termed it Peptide-Assisted Genome Editing (PAGE) CRISPR-Cas platform. This platform allows rapid and effective editing of primary cells with minimal toxicity. go.nature.com/3LB007T

In total, this provides a new model for how big animals avoid cancer - maybe they’re just better at DNA repair than us? As a next step, I’d love to see this validated in an animal model - if you drive high expression of whale CIRBP in the mouse, are they cancer-resistant?

Pioneering method for stem cell diagnostics: Leif S. Ludwig receives Paul Ehrlich and Ludwig Darmstaedter Early Career Award linkedin.com/posts/goethe-u…

We're so excited to share our latest work “Identification of astrocyte-driven pseudolineages reveals clinical stratification and therapeutic targets in #Glioblastoma” spearheaded by Oğuzhan Kaya on the wet & @LCForst on the dry lab as a preprint @Biorxiv biorxiv.org/content/10.110…

📢 We’re live at the The EMBO Journal! 🌐 tinyurl.com/39xdttna Human telencephalic organoids cultured in the absence of Matrigel endogenously produce and self-organize the extracellular matrix, without affecting programs of neuronal differentiation. Led by Catarina Martins Costa 👩‍🔬 🧵 1/5