We have been a bit quiet lately, doubting if Twitter is still a good platform for science, but this one we really wanted to share. Chancie T - chanciet.bsky.social and the rest of the team show how ECF #transporters shed off a subunit by #cryoEM, Cristina Paulino nature.com/articles/s4146…

Although we are proud of our published work, the road to publication has been demotivating for the postdocs and PhD students who scrutinised every detail of their work. Have a look at the peer review files associated with the paper, and you will see why.nature.com/articles/s4146…

A few days remain to register for #Ligand Recognition and Molecular Gating GRS to be considered as a speaker or discussion leader. Take a chance to share your fantastic #ionchannels #membranetransporters #GPCR story!

A colorful study! #CryoEM map of the substrate-bound ASCT2-nanodisc complex viewed from the extracellular side by Alisa Garaeva (Alisa Garaeva) 🔬Talos Arctica FEG transmission & scanning electron #microscope (Thermo Fisher), University of Groningen (University of Groningen) #STEM #TEM

ECF transporters never fail to surprise. Michele found a new transceptor case: biorxiv.org/content/10.110… Happy holiday break!

Looking for a PhD student to join my group studying bacterial virulence factors using cryo-EM, advanced biochemistry, and molecular biology. Modern environment, amazing colleagues, and a lively city in the Top of the Netherlands! Apply: rug.nl/about-ug/work-…

Mark's tour-de-force work shows that the ABC transporter BacA from Mycobacterium mediates unprecedented bi-directional transport of cobalamin. Great team effort with Solène and Chancie T - chanciet.bsky.social (Chancie) nature.com/articles/s4146…

An amazing GRS and GRC on Ligand Recognition & Molecular Gating has come to an end! Thank you so much GRS chairs Anna Borowska and Franziska Heydenreich for the invitation and Crina Nimigean and "Edward" Kunji for making it a truly mind and "lignand" bending experience! 😍🥳

Back from the GRC Ligand Recognition and Molecular Gating; sadly the chair Kaspar Locher could not be present but stand-ins Crina Crina Nimigean and Edmund @Mitocarriers saved the conference, together with the GRS chairs Anna and Franziska Anna Borowska Franziska Heydenreich. Thanks!

in case you all like membrane proteins, there's a lot of cool stuff in the fresh-off the press NatureStructMolBiol issue nature.com/nsmb/volumes/3…

Can AI help us to formulate new hypotheses on the known protein universe?🔎 We definitely think so! Here we describe a new "transceptor" case, linking membrane proteins involved in transport (S-components) to signal sensing (5TMR-sensor histidine kinases). nature.com/articles/s4200…

Researchers including Anna Borowska Cristina Paulino Membrane Enzymology untangle the structural basis of the exchange mechanism of Na+ -dependent obligatory amino acid exchanger ASCT2. nature.com/articles/s4146…

Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2. Nature Communications. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: pdbtm.unitmp.org/entry/8qro nature.com/articles/s4146…

If you are interested in a joined effort towards building a synthetic cell (including -of course- membrane transporters), have a look at this post: nature.com/naturecareers/…

YAY! Our paper showing insertion of the fluorescent non-canonical amino acid Anap into SERT is out. We directly measure binding of ions, inhibitors and substrates, and estimate on- and off-rates. Grateful to Novo Nordisk Foundation, DK Frie Forsk.fond & Carlsbergfondet. rdcu.be/dYkKR

Biochemical and structural characterization of the full-length CdaA reveals that efficient synthesis of the second messenger cyclic di-AMP requires membrane-bound cyclase enzyme. nature.com/articles/s4200… Cristina Paulino @DrougkasP Membrane Enzymology