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Our paper looking at the structure of retrograde IFT trains is out now! Have a look at the link, or see some of the headlines in this video: cell.com/cell/fulltext/…

Excited to be part of this study using Cryo-ET to uncover new cellular organelles!

We find members of the TMC family of putative #mechanosensors at the tips of #intestinal #microvilli! Bechara Kachar Modeling @Angelative and molecular dynamics simulations Sotomayor Lab at OSU suggest they may be ion channels and/or lipid scramblases, like TMC1 at #stereocilia tips!

Our review on the emerging roles for primary cilia in synapses and neurological disorders is now online! 😍sciencedirect.com/science/articl…

Expanding the molecular grammar of polar residues and arginine in FUS phase separation: nature.com/articles/s4158…

Our live imaging video of muscle cell fusion is hosted on HHMI's Beautiful Biology! Thanks BB for selecting our video and congratulations to Yue Lu! hhmi.org/beautifulbiolo…

New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do. rdcu.be/emtQu #CryoET #MembraneBiogenesis #Organelle 🧵1/5

3/5 Hemifusomes can exhibit lens-shaped hemifusion structures embedded within vesicle bilayers, mimicking "dead-end hemifusion" state from mathematical models. These are not fleeting intermediates, but long-lived structures with implications for protein and lipid sorting.

4/5 We propose an ESCRT-independent mechanism for intraluminal vesicle and multivesicular body (MVB) formation. Via PND-driven vesicle generation, hemifusion, and internalization, hemifusomes act as hubs for building complex MVBs - no ESCRT machinery required.

5/5 This study rdcu.be/emtQu was made possible by a fantastic team: Amirrasoul Tavakoli and shiqiong hu NIH and Seham Ebrahim UVA

Grateful to see a briefing of our new paper shared more widely always meaningful when the science resonates beyond the lab. Great collaboration with amazing scientists shiqiong hu Seham Ebrahim Bechara Kachar

Grateful to have contributed to this work alongside a fantastic team. Exciting to see it out!

New organelle found in the Human body. The organelle, which is a form of specialized structure, has been given the name “hemifusome” and may help researchers develop new treatments for disease. nature.com/articles/s4146…