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So why does it matter that glycans are genetically encoded? Glycans can be >50% of protein’s weight, cover >50% of protein surface, and vital in immunology, metastasis, and autoimmune pathogenesis. Yet, many biologists ignored them because they are hard to measure and control

Great story about my advisor Chris Voigt and his nitrogen fixation project Christopher Voigt Pivot Bio MIT Dept of BE MIT Spectrum A Plan for Plants in the Voigt Lab betterworld.mit.edu/spectrum/issue…

All you want to learn about neuro-barrier-immunity in a single review, by Sokol and colleagues. A must read. Caroline Sokol MDPhD cell.com/trends/immunol…

Have you ever wondered whether age-associated immune defects can be corrected? I am SUPER excited to share our new study from Jonathan Kagan Lab where we found that vaccines containing DC hyperactivators enables CD4+ T cells to eradicate tumors. authors.elsevier.com/a/1jFOm_278y%7…

Very excited to share our paper showing that IL-18 activation of the salt transporter NCC programs durable immune tolerance in the gut! We found that NCC induces a metabolic switch in macrophages that stabilizes fatty acid oxidation and prevents glycolytic reprogramming ⬇️

Incredibly proud of Tyler Mertens, Aditya Misra Aditya Misra, Peng Xiao and the team for figuring it out! Big thanks to Richard Flavell, Martin Hemberg, Naama Kanarek and Ana Anderson lab! Read more here Immunity: authors.elsevier.com/a/1jICr3qNrUxt…

Amazing work! Great tool to precisely tune transgene expression. Congratulations Sneha Kabaria Katie Galloway and the rest of the team! 👏🏼

on unimodal setpoints and how to get them from synthetic promoters... tweetorial coming soon... or see you next Thursday #SEED2024 in Atlanta... Stay tuned for more control systems coming soon...

Nature research paper: Glassy gels toughened by solvent go.nature.com/3xpV5lK

Thank you "She Has a PhD" podcast. It was fun. Take a listen :) youtu.be/g_AQpbndCYY?si… and this: youtu.be/sChPZnxLsJc?si… urldefense.com/v3/__https://o…$ urldefense.com/v3/__https://p…$

One UK institute has produced a dozen Nobel laureates and biomedical breakthroughs across the board. How does Cambridge’s Laboratory of Molecular Biology do it? go.nature.com/4cncxXi

Out in Cell now with added data and analysis! Huixin and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. authors.elsevier.com/sd/article/S00…

Loss of gene expression can compromise cellular fitness. In the case of such haploinsufficiency, replacement of the gene supplementation could rescue cell health. But what if you need a very precise dosage? Try ComMAND! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

Read about ComMAND below! Such a privilege to contribute to this excellent work lead by Kasey Love

Last call for abstracts (Sept 3rd deadline) ! Pls RT! This year we're especially looking for those who work in sustainability and microbiome engineering to join us! Ophelia Venturelli Tom Ellis Sonja Billerbeck Nika Shakiba @barbara_synbio

My lab at UCLA Chemical and Biomolecular Engineering will recruit 1-2 motivated graduate students to start research in Fall of 2025. Research topics include computational materials science / biophysics from a chemical engineering lens. Please encourage undergrads to visit adityanandy.github.io/co-workers/ and inquire!

We profiled embryonic CSF in a mouse model of maternal immune activation (MIA) with Bory Petrova and Lehtinen Lab. Now out in Journal of Biological Chemistry. jbc.org/article/S0021-…

cen.acs.org/materials/poly…

New paper in collaboration w/The Arpaia Lab out in Nature today! Andrew Redenti, Jongwon Im and team engineer E. coli Nissle probiotic as cancer vaccines nature.com/articles/s4158… Columbia BME Herbert Irving Comprehensive Cancer Center. Congrats all!!

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…