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Thank you Shadi Yaghi for the fantastic and comprehensive lecture! Cervical dissection is indeed “a pain in the neck”. Case Western Res Univ/UHCMC Neurology Residency University Hospitals

Congratulations Cerebrovascular & Neurointerventional Lab Aaron Rodriguez Calienes on leading this important analysis to shed light on management of extracranial ICA occlusion sub population.

Let’s admire the power of mechanical thrombectomy in stroke patients seen in this analysis from SELECT-2. Only 62 patients were included with large core & tandem lesions ASPECTS 3-5: OR 4.5 for independent ambulation & 2.5 for mRS, p<0.05. Amrou Sarraj neurology.org/doi/10.1212/WN…

Happening now in #strokeintherealworld at #ISC25 - large core clinical trials review with Amrou Sarraj AHA Science Stroke AHA/ASA NEJM SELECT 2

Proud of our PGY3 resident Ameena Shafiq for her work demonstrating no heterogeneity of association between functional outcomes and direct-to-angio suite vs repeat imaging approaches among patients who did and did not receive thrombolysis from the Direct to Angio cohort study.

#Stroke February Cover Figure: In a post hoc analysis of the SELECT-2 trial, both biological sexes enjoyed equal benefit from EVT in the setting of established large core infarction. #GoRedForWomen #AHAJournals ahajournals.org/doi/full/10.11…

So delighted to see Sex based analysis from SELECT 2 on Stroke AHA/ASA cover page!

#ISC25 Session Report: Pushing the Limits of EVT in 2024 #BloggingStroke contributor Gregory J. Wong, MD shares highlights from “Wild Wild West: Frontiers of EVT – Large Core, Mild and Distal Occlusions.” Amrou Sarraj Tudor G. Jovin, MD Mayank Goyal AHA Science ahajournals.org/do/10.1161/blo…

Women Benefit Equally From Endovascular Thrombectomy for Large Core Ischemic Stroke in a Subanalysis of SELECT2 In this #BloggingStroke post, Chloe Mutimer discusses #Stroke article by Jenny P. Tsai MD et al. #AHAJournals #GoRedForWomen ahajournals.org/do/10.1161/blo…

Not all hypodensity/ASPECTS is the same in large core. In SELECT-2, if ≥26 mL of brain tissue has ≤26 HU (severe hypodensity), there may be no benefit from EVT in large core patients & increased complications Thanh Nguyen 🇺🇦 Amrou Sarraj Stroke AHA/ASA ahajournals.org/doi/full/10.11…

Toughest lecture I ever delivered! Starting them young on #strokeawareness This Hathaway Brown preschool crowd had a lot of interesting remarks. I definitely can see some future doctors in there! Thank you Penumbra Neuro for your support with the illustrative models.

#STROKE: Review by Amrou Sarraj et al. of the six recent RCTs of thrombectomy in large core strokes with the exploration of what expanding eligibility could mean for stroke care systems and society. #ESOC2025 #AHAJournals ahajournals.org/doi/full/10.11…

Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomized Controlled Trials ahajournals.org/doi/10.1161/ST… Stroke AHA/ASA

ESO's #PaperOfTheMonth: ESO's #PaperOfTheMonth for June is out: "Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomised Controlled Trials." ow.ly/P6iL50WairO Amrou Sarraj Zhongrong Miao Osama Zaidat MD Tudor G. Jovin, MD

The July episode of the #StrokeAlert Podcast is now available. Host Dr. Negar Asdaghi highlights articles in the July issue of #Stroke and interviews Amrou Sarraj on “Mechanical Thrombectomy for Large Ischemic Stroke.” #AHAJournals #StayAlertWithStrokeAlert ahajournals.org/do/10.1161/pod…

Via NEJM: Stroke patients given tenecteplase before thrombectomy had better outcomes than those who just had thrombectomy, possibly opening the door to more research on timing/delivery: hubs.la/Q03xQTTQ0 @AANMember Eva A. Mistry, MBBS, MSCI, FAHA Amrou Sarraj Tudor G. Jovin, MD Lawrence Wechsler

The pleasure is mine! Thank you Dr. Negar Asdaghi Stroke AHA/ASA for featuring our article. Tudor G. Jovin, MD Xiaochuan Huo, MD 🇨🇳 lapergue Bertrand, MD, PhD Thanh Nguyen 🇺🇦 Jens Fiehler Osama Zaidat MD Zhongrong Miao and all the wonderful PIs of large core trials. The ultimate data from individual patient data meta-analysis