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Stress can trigger willful seeking of a starvation-like state in certain female mice predisposed to higher anxiety. Now published and downloadable here: authors.elsevier.com/a/1iyP-3BtfH9A… Congrats to lead-author Hakan Kucukdereli, Oren Amsalem, Andrew Lutas, and the whole team. Feedback welcome!

What questions should we be asking as neuroscientists, and how should we go about answering them in satisfying and innovative ways? I think that seeking training in Stephen Zhang's nascent lab NYU Center for Neural Science is a great way to find answers to these questions in an amazing environment.

Out in Cell now with added data and analysis! Huixin and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. authors.elsevier.com/sd/article/S00…

Our perspective on the frontiers of neuroscience beyond the nervous system. Thank you, Cell, for the opportunity to collaborate with our partners Nadine Gogolla and Steve Liberles. Thanks Chi Jingyi and Popescu, Miranda. My special thanks to Megan Sammons.

Pretty exciting result: disrupting cue reactivations in mouse visual cortex in the hours *after* operant training completely blocks learning.

I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3

We found that in vivo peptide release and signaling gradually enhances the response of satiety-promoting hypothalamic neurons to each bite of food during a meal. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety.

In other words, perhaps we should consider slowing down and savoring each moment.

I am thrilled and grateful to share that I’ll be starting my lab at ISTAustria in June 2025! We will study how the hypothalamus maintains homeostasis in response to challenges. Check out our website: dmhlab.org, and if interested please get in touch!

We lack tools to track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope (MORSE).

[1/4] Registration for our two-day virtual & in-person symposium in June is now open! See below for the full list of cutting-edge experts in #neuroscience and #AI speakers:

Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping. eventbrite.com/e/stand-up-for…

I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. biorxiv.org/content/10.110…

A drop of milkshake takes a wild ride after it is swallowed. Rachel and Kiersten came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.

We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet. Nice work, Marta & team!

NEW: Mark Andermann (@markandermann.bsky.social) of Harvard Medical School and BIDMC brings experimental data and computational modeling together to understand cortical reactivations. Watch the video: youtu.be/1N6i7Zi9kXs #NeuroAI2025 #neuroscience #AI #NeuroAI