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An analysis of multiple cohorts of patients with #melanoma treated with #immunotherapy uncovers #microbiome correlates of response to therapy Segata Lab Dr. Karla Lee Andrew Thomas Laura Bolte Tim Spector MD (Prof) nature.com/articles/s4159…

New #JITC article: Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer bit.ly/3CO5eHc @TerrisseSafae Andrew Thomas

Andrew Thomas no #PIO2022 Go Brazil!

Turning personal data into DNA sequences and using BLAST to link huge health-related databases. That was the idea of ​​the project Tucuxi-BLAST that has just been published. Enjoy! peerj.com/articles/13507/

Extending and improving metagenomic taxonomic profiling with uncharacterized species with MetaPhlAn 4 biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

MetaPhlAn version 4 is out! Big improvements with the possibility to profile uSGBs (i.e. MAG-defined species), better markers, ~27k tot SGBs (species), estimation of the unknowns, and more. DB based on >1M genomes+MAGs! Preprint, code, tutorials available! biorxiv.org/content/10.110…

Can we assess engraftment of donor's strains in FMT? What drives it? In our latest study Nature Medicine we examine the extent and determinants of strain engraftment upon FMT, and build ML models to predict the resulting microbiome composition (thread). nature.com/articles/s4159…

Multiple open positions in my lab! Please re-tweet and get in touch with me for any questions! Other positions will appear, looking for enthusiastic candidates not necessarily experienced in metagenomes as long as they have solid computational or quantitative background!

"The person-to-person transmission landscape of the gut and oral microbiomes". Our work on microbiome stransmission published today open-access in nature! Fantastic work Mireia Valles-Colomer, the whole Segata Lab group CIBIO - UniTrento and all the collaborators! nature.com/articles/s4158…

Very excited to announce our paper on person-to-person transmission of the gut and oral microbiomes has just been published in nature!

New #research published in JAMA Oncology shows that a Mediterranean diet can improve the efficacy of #immunotherapy for patients with metastatic melanoma. Encouraging news for #cancer patients worldwide! To find out more: seerave.org/benefits-of-me…

Is there a link between the response to immunotherapy and habitual diet in cancer patients? Excited to share with you the results of our study published today in JAMA Oncology. To learn more, check out the paper and follow this thread:

MetaPhlAn 4 is published today OA in Nature Biotechnology Nature Biotechnology nature.com/articles/s4158… We added GTDB output, improved performance and comparative analyses w.r.t. the preprint version. Huge thanks to Aitor Blanco Miguez for the eroic effort and to all Nicola Segata and hutlab

1/2 A Science and Innovation at Cancer Research UK funded study on the role of air pollution in the promotion of lung cancer has been published in nature by Charles Swanton - Cancer Grand Challenges Scientific Committee Member. Read Allan Balmain's (UC San Francisco) News & Views commentary Nature News & Views ⏬ nature.com/articles/d4158…

Happy to see this out! A personal culmination led by great scientists and mentors Nicola Segata Laurence Zitvogel & Guido Kroemer, embodying fantastic collaborative science with Marine, Bertrand & Jen, with teachings from Segata Lab Seerave Foundation #oncobiome members and others along the way

The origin of some cancers is closely related to dysbiosis. Zitvogel, Nicola Segata, Jennifer Wargo MD & colleagues discuss the role of Gut OncoMicrobiome Signatures as next-generation biomarkers for cancer immunotherapy: ow.ly/O7ig50P6Xb4

BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures go.nature.com/3PgPpzz

Expanding the Segatella copri complex. Aitor Blanco Miguez Segata Lab StrowigLab extend Segatella copri (formerly P. copri) complex (ScC) to 13 species. ScC members contain distinct genomic elements & content & display variable association to host conditions cell.com/cell-host-micr…

In NEW Nature Reviews Microbiology article, Francesco Asnicar Andrew Maltez Thomas andrea passerini Levi Waldron and Nicola Segata cover the aspects that they consider most important to enable microbiologists to use machine learning. nature.com/articles/s4157… 1/2

I'm thrilled to share our team's effort towards enabling ML usage and evaluation for microbiologists. Here goes the summary thread 🧵 1/6