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A recently published commentary in British Journal of Clinical Pharmacology (BJCP) on how statistical methods using genetic data can aid in drug development. bpspubs.onlinelibrary.wiley.com/doi/full/10.11…

New preprint: "Bias in multivariable Mendelian randomization studies due to measurement error on exposures" led by a previous summer intern student Jiazheng Zhu and post-doc Andrew Grant - arxiv.org/abs/2203.08668. Some thoughts follow!

Grant et al present a new statistical method: for clustering variants based on their proportional associations w/ chosen traits The result is more reflective of the underlying mechanisms the variants relate to Andrew Grant Dipender Gill Paul DW Kirk Stephen Burgess doi.org/10.1371/journa…

Just over two weeks to apply! A great opportunity to be exposed to the day-to-day activities of researchers in statistical methodology and statistics applied to biomedical problems. Please RT.

Our new review "Using genetic association data to guide drug discovery and development: Review of methods and applications" is now online at @ajhg: authors.elsevier.com/a/1gX1fgeX2XW7. Summarizes a lot of recent work from our group and others. Thread follows:

Congrats to our PhD student Ellen Dobrijevic on this brilliant primer on #mendelianrandomization. MR is a powerful method for dealing w/confounding to make causal inferences but needs careful consideration for robust results. Step by step guide to MR 🧭: doi.org/10.1016/j.kint…

Version v0.10.0 of the MendelianRandomization package is currently making its way to CRAN. Two major new functions: mr_clr implements weak instrument robust methods outlined in onlinelibrary.wiley.com/doi/10.1111/bi… (Anderson–Rubin, Kleibergen, and the conditional likelihood ratio test), ...