🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Interested in grad school in genetics? Check out this upcoming panel hosted by Human Genetics @ UChicago and UChicagoGGSB to learn about the application process and meet current students/faculty! 🧬

I am very proud to share our work, titled: “Allele frequency differences of causal variants have a major impact on low cross-ancestry portability of PRS“,(medrxiv.org/cgi/content/sh…)

Our new model of polygenic epistasis. We hope it's a helpful step toward precision medicine+understanding GWAS hits It's crazy that David Tang did this as an undergrad. And very appreciative of key computational assist from jerome

Very happy to see Minhui's paper out :) It was WAY more technically challenging than expected, scRNA data is complicated... But Minhui was up to the challenge, and we hope this is a step toward robust Gaussian variance component models for scRNA

The Department of Human Genetics at University of Chicago is searching for a faculty candidate in Computational genetic and genomics. Please share this job ad with your colleagues: apply.interfolio.com/127605

Excited for the 2nd annual PhD Info session with UChicagoGGSB Sign up at bit.ly/GeneticsInfo20… for application tips from a diverse panel of current PhD students and faculty! QuestBridge I'm First! LEDA Jack Kent Cooke Foundation Reach Higher @FirstgenCenter HSF Coca-Cola Scholars

Less than a week to #wcpg2023, looking forward to seeing everyone there! My lab is hiring postdocs to work on quantgen methods, EHR utilisation, disease heterogeneity and trajectories, if interested please DM, also happy to chat during the conference! nacailab.com

New paper by Andy Dahl and I on phenotype integration improving GWAS power while preserving specificity is now out in Nature Genetics 🎉 thank you all collaborators and reviewers! nature.com/articles/s4158…

Really cool paper that investigates (primarily mental health) phenotype imputation for GWAS as a trade-off between increased power versus decreased specificity. This gets at the broader conceptual question of what is a phenotype for? A few intriguing results/directions. 🧵:

Great summary. Thank you Sasha :)

Open TT faculty position at the department of medicine at the University of Chicago! Come join us in Genetic Medicine, Biomedical data science, Oncology, or any of the other sections. Apply here: academicjobs.uchicago.edu/positions/1318…

Our study on utilizing smartphones to track behavior in real-time & predict depression severity is now out in Nature Digital Medicine.  Jonathan Flint Sriram Sankararaman Eran Halperin UCLA Depression Grand Challenge

Our new work uses GxDrug interaction to model genetic effects on drug response in cross sectional data. Includes a new method for GxE TWAS. There are important caveats, but we hope this is a step toward more precise treatments

UCLA_Computational Medicine postdoc Richard Border is moving to Carnegie Mellon in Spring 2025 his own lab as an assistant professor in the CMU Department of Computational Biology. Ray and Stephanie Lane Computational Biology Dept. CMU School of Computer Science borderlab.org

Our work using gene-environment interaction methods to study the genetics of drug response is now out in Cell Genomics. Cell Press cell.com/cell-genomics/…

GxDrug interactions now published at cell genomics :) Michal Sadowski did a ton of great work in this paper. We hope the approach is a step toward improving predictions for individual-specific treatment response

Very happy to share *two* new projects from my group now on bioRxiv on mtDNA variation effects on tissue-specific gene expression conducted using RNAseq data in 49 tissues in the GTEx Portal project! 🧵 1/n

Are you an early-career researcher working on the computational analysis of population-level human genetics data? We want to hear from you about if, how, and why you use population descriptors in your research! Fill out our short survey: forms.gle/SCiNUq71wgi5co…

Congratulations to Joel on the publication of this paper in AJHG. He shows that polygenic scores derived from different quantiles of a phenotype differ, and uses this to come up with an interesting and novel test for confounds and GxE authors.elsevier.com/sd/article/S00…

🚨 Applications are open for the UCLA Postdoct Training Program in Neurobehavioral Genetics 🧠🧬 Deadline: 6/30 👉 neurogen.semel.ucla.edu/curriculum/ Contact me if you're interested to write a proposal together combining genetics, functional genomics, & digital phenotypes from smartphones!