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Super excited to see our paper, led by Dr. Helena Boutzen, released today in Leukemia Journal. We uncovered two leukemia stem cell subtypes with distinct transcriptomic, epigenetic , and functional properties. Read it here: nature.com/articles/s4137….

I am thrilled to announce that I have been selected by ASH to receive the 2024 ASH Global Research Award! #ASHAwards So excited to explore new avenues and deeply thankful for the outstanding support from my institution and mentors!

I’m particularly psyched to cheer on fellow Princess Margaret Cancer Centre Research friends/colleagues speaking Saturday at #ISEH2024 HopeCancerLab Andy Zeng @rob_vanner. Also don’t miss the poster on CD83 from team of Murtaza S. Nagree Angelica Varesi presented by Andy.

Be prepared to be wowed #ISEH2024!Stay tuned for @rob_vanner in session 7B on TET2-CH and tumor microenvironment immunotherapy response. Andy Zeng will be sharing his new findings on precise single cell transcriptomic mapping of AML LSCs in the new investigator awards session.

Dr. @Rob_Vanner is another recipient of the 2024 Clinician-Scientist Awards! Dr. Vanner is a medical oncologist and researcher at the Princess Margaret Cancer Centre, and will seek to find new ways to prevent, detect and treat liver cancers. Story ▶️ bit.ly/3XxtFEI More 👇

Priyasmita Chakrabarti (Tsvee Lapidot's Lab) will present her PhD Thesis Defense on the topic: Circadian oscillations metabolically regulate primitive hematopoietic stem cell maintenance via mitochondrial remodeling and Wnt signaling (1/2)

Incredibly proud of Angelica Varesi and Sayyam Shah for their ASH abstract achievement awards. I have the privilege of mentoring Angelica (2nd year of PhD University of Toronto w/ an oral presentation) and Sayyam (undergrad!!! University of Waterloo w/ a poster) with John Dick. #ASH24

Thrilled to present tomorrow at #ESCGT2024 our work on VEXAS syndrome

🧨💥Our latest work is out @cellreportsmedicine! We uncovered #p38MAPK mediated #proliferation stress as the culprit of functional #impairment of #HSC during exvivo #gene #editing. p38 inhibition endows edited HSC with high #clonal #output and better preserved genome #integrity!

I’ve migrated to 🦋 #ASH24 posts will be there. #ASHThrowback 10th wedding anniversary fell on Thursday of #ASH2018. What to do? Husband is also #STEM 🧪academic, so understood the importance of an oral at ASH. Celebrated in SD in 🩸style with little red dress ASH

#ASH24 like no other in #ASHaiku, Come and join us 👉 🦋 inspired This is the big time, Scientific committee, Three ASH abstracts. Slay!!! Anticipating amazing 501 talks. Moderating too! Saturday oral, New human HSC state. I’m one proud mentor. 1/

Angelica Varesi Sayyam Shah I am honored to have been selected to serve on the ASH Scientific Committee for Stem Cells and Regenerative Medicine for the next 4 years, officially starting 2025. Proud to represent 🇨🇦 #HSC. Princess Margaret Cancer Centre Research

Looking forward to presenting my PhD work at #ASH2024! If you want to hear more about the discovery of a new LT-HSC functional marker, don't miss the 501 oral session form 9.30 to 11 ash.confex.com/ash/2024/webpr… Huge thanks to my mentors John Dick and Stephanie Xie !!!

Excited to present the work of Martina Fiumara and the whole team at ASH in the poster session today. Thanks to #omics and #CRISPR editing we discovered the mechanism of clonal dominance and BMF in #VEXAS syndrome. See you there!

🔥Pre-print🔥 We show that therapy-resistant clones are selected within 1-3 cycles of IVO+VEN+/-AZA, months or years before relapse, within rare populations of persistent LSCs. Consistently, in patients with sustained remission, only WT/CH cells persist. biorxiv.org/content/10.110…

Excited to announce our latest @BloodJournal study, led by Dr. Joana Araújo. We identified FLT3 as a promising therapeutic target to eliminate ITD+ LSCs while sparing healthy HSCs. Read more: ashpublications.org/blood/article-….

DeepSeek-R1 is great, but it still does not handle genomics yet :) 🚀 We’re thrilled to announce that IntegrAO (pronounced "integral") 🧬🔬—our new multi-omics integration framework—has been published in Nature Machine Intelligence! 📑 Paper: nature.com/articles/s4225… 💻 Code:

Our researcher Stephanie Xie's News & Views article is published in Nature Immunology🎉 It highlights work from Stanley Adoro’s team on how the IRE1α–XBP1 pathway plays a surprising role in safeguarding blood stem cells while suppressing leukemia-promoting programs: nature.com/articles/s4159…

I am thrilled to announce I am the newest Scientist Princess Margaret Cancer Centre. The Xie lab will focus on understanding how inflammatory and metabolic stress in human hematopoietic stem cells promote aging and cancer risk and preventative interventions. Recruiting…

Excited to announce our latest preprint is finally out! Huge collaborative work shared with Murtaza S. Nagree and supervised by Stephanie Xie! 😍 Check it here! biorxiv.org/cgi/content/sh… University of Toronto University Health Network Princess Margaret Cancer Centre