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May must-reads📖: 1) cuaj.ca/index.php/jour… 2) cuaj.ca/index.php/jour… 3) cuaj.ca/index.php/jour…

#ASCO22 Congrats Anil Kapoor, MD, FRCSC on such an elegant discussion of 3 top #kidneycancer abstracts on belzutifan, cabozantinib+batiraxept, & the 1st live bacterial product during efficacy in mRCC👉Future is bright 👇Sumanta K. Pal, MD, FASCO Fabio Schutz Eric Jonasch Nazli Dizman OncoAlert ASCO

So disappointing !

Do differences matter in adjuvant #RCC IO-trials? Known variables: 👉 6 vs. 12 mo. of treatment 👉 M0 vs. M1/NED + M0 👉 #Pembro vs. #Nivo±Ipi vs. #Atezo Big unknowns are: 👉 role of pT2 vs. pT3 vs. N1 👉 sensitive subgroups (such as sarcomatoid, PD-L1+)

Grateful to The Lancet for allowing us to publish our experience with #adjuvant #atezolizumab (#IMmotion010) simultaneous w the presentation by #AxelBex at #ESMO22. It's interesting to envision how this data impacts current landscape (link below): (1/10) thelancet.com/journals/lance…

Thank you to all the Canadian patients (and world wide) that participated in this study. I agree AKL, more to come !

Happening now: GU non prostate mini orals Camillo Porta shows update of CLEAR study, median f/u 33 months: - PFS maintained across risk groups - ORR 17%, primary PD 5% - longer f/u needed for good risk - reading out for pts post 2 years Pembro, encouraging #ESMO22 ESMO - Eur. Oncology Toni Choueiri, MD

CLEAR study update, with significant contributions from Canadian patients and PI Naveen Basappa, MD Eric Winquist Kidney Cancer Canada Pembro Lenvatinib promising option for RCC patients !

CLEAR study update - CR rate still impressive! Naveen Basappa, MD Kidney Cancer Canada Mirjanac

negative study adjuvant Ipi-Nivo in high risk RCC. We still have options for Canadian patients - adjuvant Pembrozilumab recently approved post surgery for high risk Kidney Cancer Canada and adjuvant clinical trials available CCTG Canadian Urological Association CUAJournal

Our own Aly-Khan Lalani entrenching Juravinski Research Institute McMaster Health Sciences on the GU Oncology landscape ! Great job !

I think it’s the highest risk patients that should be included, not pT2a grade 3 (ie 7 cm resected tumor grade 3) probably would not benefit from adjuvant therapy, look for forward to subset analysis of those that would benefit ! Kidney Cancer Canada Canadian Kidney Cancer information system (CKCis) Canadian Urological Association

Cabozantinib/ipilimumab/nivolumab triplet hits DFS primary endpoint (vs ipi/nivo). RR 43% +CR 3% are modest. 32% increase in G3/4 toxicity may be explanation. Benefit seem ⬆️ in intermediate risk pts. OS is going to be important for things to significantly change #ESMO22

#ESMO22: remarkable data continues to return for #RCC! Toni Choueiri, MD delivers COSMIC-313 triplet data + touching tribute, eloquently discussed by Sumanta K. Pal, MD, FASCO. State of union expands… Tom Powles Brian Rini, MD Robert Motzer MD Laurence Albiges Rana McKay, MD, FASCO Daniel Heng Bradley McGregor OncoAlert

Should the selection of 2L treatment for metastatic #UrothelialCancer be based on PD-1 expression? Braden Millan and Anil Kapoor, MD, FRCSC discuss for #ASCODailyNews: fal.cn/3s5WM #gucsm #blcsm #kcsm

Congrats Braden ! You continue to be a rockstar- as the Emperor said to Anakin, “I look forward to your career with great interest !”

Mortality According to Treatment in Metastatic Collecting Duct Renal C... sciencedirect.com/science/articl…

Well done Braden Millan for all your hard work on this JU paper ! McMaster Urology McMaster Surgical Education Research

JUST IN: Cytoreductive Nephrectomy for Metastatic RCC Treated with Immune Checkpoint Inhibitors or Targeted Therapy: The IMDC does it again ! #IMDC Daniel Heng with Talal El Zarif, MD Ziad Bakouny, MD, MSc Shaan Dudani et al in European Urology secure-web.cisco.com/1nOqqWr2rKW30O…

Pat Hart has been a dedicated St. Joseph’s Hospital Hamilton cleaner for 32 years, retiring today, every clinic this amazing colleague would bring me water as I finished clinic. You will be missed Pat ! @STJOESHAMILTON