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How do you find a needle in a genomic haystack? Yeast yields some answers here, thanks to Xless Agnès Dumont, Nicolas Mendiboure, Jérôme Savocco, Daniel Jost et al. Free here for 50 days, or very similar preprint here: x.com/aurelepiazza/s… Enjoy!

Super work from Asha Mary Joseph, Inchara Adhikashreni et al on replisome speed variation in Caulobacter!

Huge thanks to Anjana Badrinarayanan and Nitish Dua for spotlighting our work in The EMBO Journal ! 🙏🧬 Check out the full article here 🚀🔬 embopress.org/doi/full/10.10… #mtDNA #mitochondria

Mechanism of DNA entrapment by the MukBEF SMC complex and its inhibition by a viral DNA mimic biorxiv.org/cgi/content/sh… #biorxiv_molbio

Excited to be featured in a childhood favourite Tinkle Magazine! Thanks to National Centre for Biological Sciences communications team for this super fun initiative.

If you haven't already, check out the Hachiman phage defence system characterised by the B Cell. Inspiring work and scary 'phantom' cells (perfect for Halloween!) 👏 cell.com/cell/fulltext/…

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Timescales in Cell Biology

Félix Ramos-León took on a ~50-yr-old mystery in #Staph aureus cell biology and came out on top! Check out his paper on how #Staphylococcus aureus chooses its cell division plane, how it forms clusters, and why all this matters during infection... nature.com/articles/s4156…

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology biorxiv.org/content/10.110…

This was an amazing collaboration, we had the luxury of years of great conversations with Wallace Marshall and his team, as well as our other HFSP partners Anjana Badrinarayanan and Johan Paulsson. Thanks for telling the story here, Wallace!

Fun work on the regulation of the bacterial SOS response to DNA damage. Led by the fantastic Aditya Kamat!

Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now PNASNews: pnas.org/doi/10.1073/pn…. MIT Biology MIT Science @HHMINews See quoted thread on the updated preprint for details:

When does a DNA polymerase degrade DNA? Read Akshaya’s latest work from the lab to find out more!

In our study in Science Advances, we reveal how ssDNA binding activates transcription factor PafBC, triggering the DNA damage response in #Mycobacteria. Read more: science.org/doi/10.1126/sc… 🔬 Cryo-EM structure 🧬 ssDNA-WYL domain interaction

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on bioRxiv ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: biorxiv.org/content/10.110… #mitochondria #mtDNA

Delighted to share this. A novel H4 variant that modulates chromatin to mediate salt stress response. This mammoth work was driven to perfection by Vivek Hari Sundar, a wonderful PhD student who also taught me. We report its CryoEM structure & unusual chemistry National Centre for Biological Sciences 1/3

🚨 Just out in Science: 2/3 of bacterial gene families have a preferred position on the chromosome—and natural selection put them there! science.org/doi/10.1126/sc… Heinrich-Heine-Universität Düsseldorf CEPLAS

🚨“Ripping bacteria to shreds” 🚨 VCP/p97, a cellular AAA-ATPase, targets and then using its tweezer like action rips apart bacteria, protecting us from infections. A thread 🦠💥#MolecularMachines #HostDefense #cellularimmunity #microbiology Nature Microbiology