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Nyet Zero.

Fantastic paper by the HOVON-SAKK AML group in @BloodJournal corroborating equally poor outcomes in TP53mut AML & HR-MDS. We need to define a new sub-classification of TP53mut MDS/AML w/ clinical trials evaluating novel Tx’s for both HR-MDS & AML. ashpublications.org/blood/article/…

Moving the needle for MPN-related inflammation with Dr Fleischman - do kimchi & kefir hold the answer? @leedshaem ⁦European Hematology Association⁩ #EHA2022

Great to see the initial Magro data for TP53mut AML at EHA2022: much work remains - are triplets the answer? Looks like allografts aren’t going away anytime soon..@leedshaem European Hematology Association

NPM1 mutant AML just got a little more complex…Valuable real world data from Dr Hernandez-Sanchez & the HARMONY Alliance - just how much risk stratification will the average clinician tolerate? ⁦@leedshaem⁩ ⁦European Hematology Association⁩ ⁦HARMONY Alliance Foundation⁩ ⁦⁦#AML

For hemepath enthusiasts everywhere, does the route to the mysterious pseudoPelger Huet anomaly lie in the spliceosome? Great work from Dr Su & the Slush lab @leedshaem European Hematology Association #hemepath

ELN 2022 is here! All change for AML as unveiled by Prof Dohner - FLT3 allelic ratio & MDS-excess blasts are out, in comes MDS/AML - makes a lot of sense for patients, a little more work for the bio-informaticians…#AMLsm #EHA2022 European Hematology Association @leedshaem

The new ELN2022 AML risk classification is here ! A welcome simplification away from allelic ratio, MRD moves to the fore for NPM1. Strong argument for timely NGS reporting & upfront tissue typing if transplant-eligible #AMLsm #EHA2022 European Hematology Association @leedshaem AML Hub

The case for re-branding ‘not-so benign’/non-malignant haem as Classical Haematology - a smart idea for a huge field ⁦Sickle Cell Society⁩ ⁦@leedshaem⁩ ⁦European Hematology Association⁩ thelancet.com/journals/lanha…

What is the risk conferred by my disease? One of the hardest questions to answer in medicine. A on the development of the International Prognostic Scoring System Molecular in MDS published today bit.ly/3aNEU64

EHA2022 ends with a bang! Immunotherapy in B-cell disease, a call to action on increasing access to new therapies for the majority of sickle patients, & the IPSS-M finally lands with improved risk stratification for half of MDS patients. #MDS #EHA2022 @leedshaem European Hematology Association

Ridiculous. #onlyinleeds

I can tolerate racism, sexism, homophobia, lies, bullying, a cost of living crisis and partying while tens of thousands of people died, but I draw the line at bad polling

Word of the day is Zugzwang [tzoog-tzwung]: a situation in chess (and life) in which a move must be made, but each possible one will make the situation worse.

Is there anything more dangerous than a god who doesn't know what they want? Yes: a whole pantheon of them.

For those who don't fully understand what is up with the NHS, here is a thread for you that might help. I'm a consultant physician working as a doctor in the NHS in Yorkshire and Wales for 32 years now. I have experienced the NHS at its best (2008) and its worst (2022).

Look. I've said it before and I'll say it again. If Harry has a problem with his family then he needs to persuade the French to fund him, raise an army, invade and seize the crown. What else was Brexit for, if not to restore traditional British approaches and values?

Sorry to keep banging on about this, Rishi Sunak, but we do think you're on to something here. Perhaps we could all get access and maybe we could repair all the damage Brexit has done. Just a though. Let us know what you think! Sincerely, the UK.

Much excitement in the family whatsapp group this morning at the prospect of an Indian and a Pakistani bringing about the partition of Britain