Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s42255… A tremendous collaborative effort led by Johanna Siehler, Sára Bileková and other members of the Heiko Lickert lab.

The Alexander Disease Protein GFAP Drives Mitochondrial Fission biorxiv.org/content/10.110…

Rare uses of this platform to propagate amazing science. Amazing to see this out.

Happy to see our POTATOMap tool & story about biosynthetic LAMP trafficking published. Tool in addgene, proteomic raw data available. See 👇

Mutations in the TANGO2 gene cause severe cardiomyopathies and rhabdomyolysis, particularly under stress. Lujan, Malhotra et al. Centre for Genomic Regulation (CRG) demonstrate that TANGO2 is an acyl-CoA binding protein located in the #mitochondria lumen. hubs.la/Q038Ny1w0 #metabolism

Check out this cool super-resolution imaging of the Golgi apparatus from my friend and collaborator, Maohan.

One month left to apply! Our lab is looking forward to new PhD students with interest in stem cell/ cancer biology and metabolism. Experience and enthusiasm for novel microscopy and /or genomics methods would be very welcome. Please see the ad below for app details.

Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites biorxiv.org/content/10.110…

Structural basis of lipid transfer by a bridge-like lipid-transfer protein nature.com/articles/s4158…

🗓️ New Deadline: Apply by 15 June 2025 Join our dynamic research community and contribute to pioneering science and innovation. 🔬 Open Positions: • 03 Staff Scientist-III • 08 Staff Scientist-IV 📍 Key Research Areas: Immunology | Infectious Diseases | Precision Medicine |

LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels: nature.com/articles/s4146…

Farewell America. I am leaving with many new and deep connections and bonds built over the years. I am very content and proud of what I could do as a postdoc especially with positive news on a manuscript in the last few days. Hopefully the next chapter begins soon.

Amazing time spent Lodha Genius Programme Ashoka University with the students for the microscopy in life sciences module with some old colleagues and friends Joseph Mathew Kalappurakkal. Thank you anupama ambika for the opportunity.

We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: biorxiv.org/cgi/content/sh…

After working on the protein (Hedgehog) during PhD, first time seeing Sonic Hedgehog in the backyard

2025 Nature Index: Harvard has dropped to No. 2 after the Chinese Academy of Sciences. No. 1 and 3-9 are all Chinese research institutes. Meanwhile, American research institutes are facing a 43% cut in NIH funding and a 50% cut in NSF funding. Please, don’t look up.

We are excited to welcome our 1st cohort of PRISM fellows! The fellowship, in collaboration with Project EduAccess is a 2-month, residential research programme designed to nurture next generation of life science researchers from underrepresented & marginalised backgrounds in India.

Nice to see such initiatives at many more places in India