
Agnieszka Obarska
@aobarska
ID: 278943396
08-04-2011 08:24:13
26 Tweet
164 Followers
61 Following

Happy to share my first model of the nuclear pore complex. Stay tuned for more ;-) Thanks to Martin Beck Laboratory and Jan Jan Kosinski for the opportunity to work on such an amazing project, and all other people involved in this great collaboration.



A special issue of Science Magazine reveals the exquisite structure of the human Nuclear Pore Complex - one of the largest proteins in nature and the gateway to the cell nucleus. It was reconstructed by integrating cryo-EM data with predictions from #AlphaFold - amazing to see!

(1/1) Out at Science Magazine our (yet) best structure of the human nuclear pore. Together with Jan Kosinski and Hummer Lab. Thanks to Agnieszka Obarska Marc Siggel @s_mosalaganti! EMBL Max Planck Institute of Biophysics #AI #Alphafold #nuclearpores #cryoET science.org/doi/10.1126/sc…

Nuclear pore structures by Agnieszka Obarska now available for download! With #AlphaFold's confidence score pLDDT in the b-factor column!







#EMBOStructBio is open for applications 🧬🧩🕵🏻 Learn how to analyse and interpret experimental data and construct structural models across different resolution scales. 💻👌🏻 📅 17 – 24 Nov 2024 📍 EMBL Hamburg ✍🏻 Apply by 25 Aug ➡️ s.embl.org/stb24-01 #EMBL50 #AI



Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to Agnieszka Obarska for the idea.
