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Rational strategy is powerful for reducing the efforts and cost on protein engineering. Our recent paper in ACS Catalysis reported the reversal of protein's steroselectivity by screening less than 10 mutants. Just like a sniper, one bullet, one target. pubs.acs.org/doi/full/10.10…

Exploiting Anion-pi Interactions for Efficient and Selective Catalysis with Chiral Molecular Cages (Wang) onlinelibrary.wiley.com/doi/10.1002/an…

We are very pleased to learn that the open access version of our article "Enantioselective biocatalytic desymmetrization for synthesis of enantiopure cis-3,4-disubstituted pyrrolidines" is now available online. doi.org/10.1016/j.gres…

This new journal, Green Synthesis & Catalysis, is dedicated to publishing high-impact research discoveries and results from academic and industrial laboratories on sustainable synthetic technologies for molecule construction and production. Excellent! sciencedirect.com/journal/green-…

I am very pleased to share our recently results in Adv. Synth. & Catal., on the amidase engineering for its enantioselectivity modification. Congratulation to Dr. Hui-Juan Hu! onlinelibrary.wiley.com/share/author/T…

Modification of the Enantioselectivity of Biocatalytic meso-Desymmetrization for Synthesis of Both Enantiomers of cis-1,2-Disubstituted Cyclohexane by Amidase Engineering (Ao) onlinelibrary.wiley.com/doi/10.1002/ad…

pi-Face Promoted Catalysis in Water: From Electron-deficient Molecular Cages to Single Aromatic Slides (Wang) onlinelibrary.wiley.com/doi/10.1002/as…

Cation-chloride cotransport mediated by an ion pair transporter - now published in Organic & Biomolecular Chemistry. Congratulation to Jun Zhu and Xu-Dong Wang! pubs.rsc.org/en/content/art…

Thanks and congratulations to Peng-Wei and Prof. Zhou! Wonderful work! Enantioselective Synthesis of Cα-Tetrasubstituted N-Hydroxyl-α-amino Nitriles via Cyanation of Ketonitrones Using Me2(CH2Cl)SiCN pubs.acs.org/doi/10.1021/ac…

Wooow, the third paper from Na Luo in 2021, Congratulations! a Putting anion‐π interactions at work for catalysis …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

"Dimensions – Naphthalene-Pillared Benzene Triimide Cage: An Efficient Receptor for Polyhedral Anions and a General Tool for Probing Theoretically-Existing Anion-π Binding Motifs" has published in CCS Chemistry. Congratulation to De-Hui Tuo! chinesechemsoc.org/doi/10.31635/c…

Structure- and Data-Driven Protein Engineering of Transaminases for Improving Activity and Stereoselectivity (Uwe T. Bornscheuer and co-workers) Yu-Fei Ao 敖宇飞 Uni Greifswald #openaccess thanks to #projektDEAL onlinelibrary.wiley.com/doi/10.1002/an…

An Artificial Single Molecular Channel Showing High Chloride Transport Selectivity and pH-Responsive Conductance (Dexian Wang and co-workers) Dexian Wang @ucas1978 onlinelibrary.wiley.com/doi/10.1002/an…

Our new molecular hourglass, beautiful and effective.

Machine learning-assisted amidase-catalytic enantioselectivity prediction and rational design of variants for improving enantioselectivity University of Chinese Academy of Sciences Nature Communications nature.com/articles/s4146… Biocatalysis is an attractive approach for the synthesis of chiral pharmaceuticals and fine

Research Highlight now online: Predicting enantioselectivity for diverse substrates by Ali Stoddart nature.com/articles/s4416… ($) Highlighting the Nature Communications article by Lin Shen, Xuebo Chen, Yu-Fei Ao and co-workers

👉Have you read the #research article Machine learning-guided protein engineering to improve the catalytic activity of transaminases under neutral pH conditions by Yu-Fei Ao 敖宇飞's team? #biocatalysis #enzyme #machinelearning 🔗doi.org/10.1039/D5QO00…

Just published our Perspective review in Chem Catalysis: “Machine learning-assisted protein engineering for improving stereoselectivity.” 🚀🤖🧬 #ChemCatalysis #MachineLearning #ProteinEngineering #Catalysis sciencedirect.com/science/articl…