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i get that hardships are the fire in which your future self is forged but sometimes da fire too hot and ouchie

im like the opposite of machine learning. human forgetting

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…

big day for elmo! so thrilled to finally share this work, showcasing how a small molecule can act as a chemical facsimile of E3 ligase cancer mutations to induce neodegradation😮 eternal goosebumps 🤯 big thx to all our collaborators 🫶

Excited to share our latest work, where we develop TDAC-seq to simultaneously map CRISPR-induced genetic variants & chromatin accessibility at targeted genomic loci by leveraging a dsDNA cytidine deaminase, DddA. Highlights below: 1/11 biorxiv.org/content/10.110…

super cool work by my super talented and hardworking lab mates!!! merry christmas indeed

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

so happy the final version of this is finally out! had the time of my life working on this super cool project with super talented people 🫰

This new drug mechanism mimics some cancers go.nature.com/430hcg7

I was happy to write a nature News and Views on the amazing discoveries by Brian Liau & Ning Zheng lab on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Nature News & Views nature.com/articles/d4158…

Woke up early. There was no worm.