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Job alert: Interested in pancreatic beta cells, a dash of genomics and novel treatment options for diabetes? We are looking for a post-doc!! Contact us for an informal chat! edzz.fa.em3.oraclecloud.com/hcmUI/Candidat…

15 years ago we published our initial study showing persistent TSH receptor signaling after internalization. I would have never imagined endomembrane GPCR signaling would become such a hot topic! Check out our review on #endomembrane #GPCR #signaling just out in Trends in Biochemical Sciences

From RAMPs to now MRAPs The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling biorxiv.org/content/10.110…

Getting busy! Still plenty of time to come take part in lots of science experiments & crafts for #DiabetesAwareness family fun day until 12 noon! We are talking about type 1, type 2 & gestational diabetes today! 🥼🔬🧪 Follow signs from Medical School at University of #Birmingham

What can't MRAP2 do? #GPCR Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways biorxiv.org/content/10.110…

Well done 👏 to our team members for winning prices for best #festive outfits at yesterday’s Metabolism and Systems Science (MSS) #Christmas 🎄 party 🎉

Open Access: A proof-of-concept study provides evidence for the development of potent multi-receptor antagonists capable of blocking both #CGRP & #PACAP activity …adachejournal.onlinelibrary.wiley.com/doi/full/10.11… Zoe Tasma Margaret Brimble Debbie Hay

Another (very good) addition to the dual peptides library pubmed.ncbi.nlm.nih.gov/39995298/

Genes that make humans and Labradors more likely to become obese identified birmingham.ac.uk/news/2025/gene…

Day 1 of SfE BES 2025

Thank you to the organizers for giving me the opportunity to present our work with #melanocortin receptors and modulation by the accessory protein MRAP2 #SfEBES2025 #GPCR #metabolism

Had a great time at #SfEBES2025! Great scientific sessions and networking! And great Metabolism and Systems Science (MSS) and College of Medicine and Health (UoB) participation! Well done to all award winners!

What a way to end the #SfEBES2025 conference! Super happy with the Society for Endo award for best oral comms in the neuroendocrinology and pituitary session alongside other Metabolism and Systems Science (MSS) and Birmingham Adrenal Team awardees #GPCR #melanocortin #metabolism

Genes that make humans and Labradors more likely to become obese identified but researchers say effects can be over-ridden with a strict diet and exercise regime: birmingham.ac.uk/news/2025/gene… #obesity #research Caroline Gorvin College of Medicine and Health (UoB) Wellcome Aqfan Jamaluddin

Congratulations to Selvambigai Manivannan (right) who was awarded the best poster for Endocrine Cancer and Later Effects at Society for Endo #SfEBES2025. Congratulations also to Aqfan Jamaluddin (left) for the best oral comm in Neuroendocrinology and Pituitary. College of Medicine and Health (UoB)

Where are we now with biased receptor signalling and what does it mean for therapeutic development. See our review here sciencedirect.com/science/articl…

Finally got this off the ground. GNAS variant GOF leading to constitutive activity linked to Cushing's. Not the first time this GNAS variant is spotted, but the first time characterised properly for its functional effect. eo.bioscientifica.com/view/journals/…

Great time at #ENDO2025 Glad to see such active Metabolism and Systems Science (MSS) participation! Amazing programme brought about by our own conference chair Niki Karavitaki! UoB School of Medical Sciences College of Medicine and Health (UoB) Endocrine Society