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Neat article comparing somatic mutations in skin in the UK versus Singapore (keratinocyte cancer risk substantially lower in the latter) nature.com/articles/s4158…

Online Now! Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths #stemcells dlvr.it/StdcSQ

✂️Splice splice baby!✂️ New paper just out in Cell Stem Cell integrating Oxford Nanopore long read single-cell isoform mapping into our broader genotype-phenotype vision for clonal mosaicism ! authors.elsevier.com/a/1hat96tu0Cm5…

Thrilled to share my work on Nature Genetics. It's not just TFs! A lineage dependency map for chromatin factors in hematopoiesis. Great mentorship by Brian Huntly and awesome collaboration with Nikolaus Fortelny. With Julen M, Nisha Narayan Jake P. Taylor-King. nature.com/articles/s4158…

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics go.nature.com/2EaExlT #Review by Anna Nam, @ChaligneRonan & Dan Landau @NYGenome Weill Cornell Medicine Weill Cornell Medicine Meyer Cancer Center

GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: nature.com/articles/s4158… 👇🧵

Nature research paper: Mapping genotypes to chromatin accessibility profiles in single cells go.nature.com/4adLUSS

🥳new pre-print alert! VEXAS syndrome deciphered - From single-cell genotype-to-phenotype mapping aaaall the way to mechanism and therapeutic vulnerability discovery! biorxiv.org/content/10.110…

Finally out! Great collaboration ScaddenLab Jason Buenrostro Epigenetic heterogeneity of the clone of origin shapes phenotypic responses in clonal hematopoiesis - we uncover a Sox4-high state that predisposes Tet2 mutant clones for dominance. Nature Communications doi.org/10.1038/s41467…

A major problem with cell-free tumor DNA to detect cancer (Liquid biopsy) is its very low quantity. Today Nature Medicine use of #AI to overcome that issue with impressive results for radical signal-to-noise enrichment nature.com/articles/s4159… free access rdcu.be/dKNOx

🎉 The dream is coming true! I'm thrilled to share that I will be returning to Montreal in Jan2025 to open my lab at Centre de recherche du CHUM and École de technologie supérieure! We'll be dedicated to advancing precision oncology, developing cutting-edge omic tools to enhance patient care. 🧬 #newPI

So proud of Joe Pelt ! A rising 💫 mdphd.weill.cornell.edu/news-and-event…

Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution", from an amazing collaboration with Dan Landau Andrew R. D’Avino Tamara Prieto Toshiro Hara Mario Suva! A tweetorial, or Xplanation ... nature.com/articles/s4158…

“Plasticity is a tremendous enabler of #cancer spread and treatment resistance, and we expect this new tool to give us critical insights into those processes," Dr. Dan Landau (Dan Landau), an WCM Englander Institute for Precision Medicine member, to Genetic Engineering & Biotechnology News on his Nature Genetics work. genengnews.com/topics/cancer/…

Lab website is now live! Stop by and take a look: izzolab.org

🎉Excited to present our latest work out today nature 1.What gives a leukemia its phenotype – the oncogenic driver or the differentiation stage of the cell-of-origin? 2.Why do RAS mutations always happen late in AML? 3.Who will relapse after VEN? nature.com/articles/s4158…

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting.. Check it out here: biorxiv.org/content/10.110… #Genomics #Epigenetics

Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon

It's the Silicon Valley approach: move fast and break things. But instead of breaking a social media site or an app that lets you take pictures of dogs, he's breaking the US's century of worldwide scientific and research dominance and system of basic consumer protections.

Delighted to share my PhD thesis work is now published in nature! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynamics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis nature.com/articles/s4158…