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New #mathonco blog post ! My colleagues and I present Biophysically-Constrained GBM Predictions via Deep-Learning Integrating Structural SINDY with Mechanistic Filters, a new line of work that we started at BIRS earlier this year. Check it out ! mathematical-oncology.org/blog/gbm-predi…

This week in #MathOnco: Plasticity, adaptive therapy, drug tolerance, and more... Artist: MeiLu McDermott (Maclean lab)!

"Bringing evolutionary cancer therapy to the clinic: a systems approach" nature.com/articles/s4154…

How can physics contribute to understanding the evolution of complexity? Although great results have been produced over the last decades, some recent "theories" appear to ignore evolutionary theory and are seriously flawed. Check this paper in PNAS pnas.org/doi/abs/10.1...

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.

This week in #MathOnco ~ last issue before the summer break! Sign up here: mathematical-oncology.org/newsletter Art: Jill Gallaher & Sandy Anderson

NEW content online! Acquired resistance in cancer: towards targeted therapeutic strategies bit.ly/3SABwye

Todays IMO research in progress is from #AndersonLab member and Oxford Mathematics student Yunli Qi presenting, Learning Optimal Adaptive Therapies in Space and Time: Dynamic Threshold Therapy Moffitt Cancer Center

Very happy to share our new paper on LLM-based tumor board agents. Submitted August 2024, published in Nature Cancer today ☺️ Led by Dyke Ferber nature.com/articles/s4301…

Gergely Rost opens the HCEMM Summer School on “Mathematical Modeling in Cancer Research” First lecture: Joel Brown from Moffitt Cancer Center

Day 2 of lectures from the HCEMM Cancer School in Szeged Hungary. Lectures begin with PDE’s taught by Tommaso Lorenzi. We are in the beautiful city center today!

Big shout out to rising M4 and MSTP at Case Western Reserve University student Eshan King - whose paper came out in Science Advances connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco Michael Baym CWRU School of Medicine Cleveland Clinic Lerner Research Institute science.org/doi/10.1126/sc…

NEW content online! Neuro-immune cross-talk in cancer bit.ly/3TuULJG

Absolutely insane amount of data in this resource from Chris Mason The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs biorxiv.org/content/10.110… Spatial data on 15million cells from 100 donors across multiple ages, mainly GI

What's heritable and what's plastic in cancer drug resistance? The two are linked! (Epi)genetic molecular memory is under Darwinian selection but encodes multiple plastic phenotypes. We found this with organoid experimental evolution + ML for multiomics. aacrjournals.org/cancerres/arti…

Online Now: Senescence in cancer dlvr.it/TLR0KV

Here is an overview of Integro-Differential equation framework called "Lenia" that we implemented in HAL Library w/ Sadegh Marzban. Slide 1: local interactions (single cell type) Slide 2. local interactions (multi-cell type) Slide 3. farther range interactions Slide 4.

Can we discover the rules of morphogenesis, tissue formation and tumour growth from spatial biology data using AI? We designed *stochastic* Neural Cellular Automata to model the temporal dynamics of biological tissues, from development to cancer. arxiv.org/pdf/2506.20486

'Night science' is what you do when you're not sure what's the question.

The math oncology newsletter is BACK from summer break, starting off with an epic art design from Kevin Painter, Chiara Villa and Tommaso Lorenzi -- based on the paper "Phenotype structuring in collective cell migration: a tutorial of mathematical models and methods"