Using the DUB mutant mice together with cell biology, XL-MS, and cryo-EM, we show that K63-Ub of A-complex substituents engages the RAP80 UIM domains. This prevents ubiquitin recognition at damage sites. DUB activity removes K63-Ub to license A-complex DDR function. 3 of 3.

A shout out to postdoc Arindam Datta for doing a great job to finish the story! rupress.org/jcb/article/22….

Congratulations to Tianpeng Zhang Tianpeng Zhang on his paper at Nature rdcu.be/dewZB describing PCNA-Ub directed resection for template switch during Break Induced Replication at telomeres. Great collaboration with Patrick Sung and Yashpal Rawal

Please also see: pennmedicine.org/news/news-rele…

Collaboration between PCGI Director Roger Greenberg (Roger Greenberg UPENN) and Elton Zeqiraj (ergiola Zeqiraj Leeds) reports a new mechanism that ensures replication fidelity. cell.com/cell/fulltext/…

Very excited to see our work on replisome proteostasis by 55LCC published in Cell . Great collaboration with @FoglizzoMartina ergiola Zeqiraj @RobertLDilley Arindam Datta

Please see our latest findings on how BLM helicase orchestrates the damage response that executes Alternative Lengthening of Telomeres. cell.com/molecular-cell…. Great work from Haoyang Haoyang Jiang and Tianpeng Tianpeng Zhang in collaboration with Hardeep Kaur and Patrick Sung.

🌟Exciting News!🌟 We are thrilled to share that our recent paper has been published in Nature Communications! Our findings reveal that DCAF15 controls cohesin complex recycling and preserves replication fork integrity to sustain AML cell proliferation. nature.com/articles/s4146…

Join us in beautiful Ventura for the 2025 GRC meeting, Mammalian DNA Repair: Fundamental Mechanisms to Human Biology grc.org/mammalian-dna-……… Great program, including keynotes from David Pellman and Maria Jasin. We will be selecting talks and poster slots soon. Apply now!

We enjoyed a great round of talks by Alberto Ciccia (Columbia), Lee Zou (Duke), Dr. Agnel Sfeir (MSKCC), and Ranjit Bindra,MD/PhD (Yale), plus our trainees Arindam Datta and Azrin Jamalruddin at yesterday’s PCGI Mini Symposium on "Targeting the Damage Response"

Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

We are excited to report work from PCGI Director Roger Greenberg together with Elton Zeqiraj and Joe Salvino on the discovery of BIRSC deubiquitinating enzyme inhibitors for inflammatory indications rdcu.be/edRwF.

New research out in NatureStructMolBiol provides insight into the molecular glues that inhibit deubiquitylase activity & inflammatory signaling ft. Smita Bhutda, Arindam Datta, Daniel Stein & Roger Greenberg (Univ. of Pennsylvania Department of Cancer Biology) nature.com/articles/s4159…

Roger Greenberg we are looking forward to your presentation at #IOSCD25 in Malta🇲🇹 Please share with your followers to let them know remaining talks will be selected from abstract submissions! 💰Grants available 📆Talk sub: 07 August 2025 ✅bit.ly/IOSCD25_TalkSub