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What happens when IgAN and ALECT2 Amyloidosis collide in a patient's biopsy? Dr. Alan Lim and Dr. River Charles walk us through a fascinating collision case with these 2 diseases in the latest episode of Collidescope. Check it out! youtube.com/watch?v=6FIu7I… #renal #pathX

This 75-year-old patient presented with slowly progressive generalized muscle weakness of approximately 2 years’ duration. What is your diagnosis based images from figures #1 - #4? #NeuroNotes #neuropath #pathology #neuromuscularpath

The differential diagnosis of acute renal failure in patients with multiple myeloma includes light chain cast nephropathy, amyloidosis, and monoclonal immunoglobulin deposition disease, among other possibilities. On occasion, patients with light chain cast nephropathy have large

The electron microscopy image provided is that of a proximal tubule and demonstrates confluent "powdery" or "pellet-like" deposits along the tubular basement membrane consistent with a diagnosis of light chain deposition disease (LCDD), the most common subtype of monoclonal

ANSWER: Amyloidosis The abnormalities are consistent with relatively abundant deposition of amyloid within blood vessel walls (vascular amyloidosis) and within the endomysium (parenchymal amyloidosis). Congo red stain is not specific as to the subtype of amyloid forming

This acellular scanning EM from a biopsy with membranous lupus nephritis shows glomerular basement membrane (large arrow) with a reticular appearance and occasional “craters” (small arrows) surrounding sites of extracted deposits. Photo credits to Dr. Bonsib! #eyeSCANdy

A sample from the pathology teaching slide set on Minimal Change Disease in Adults, jointly prepared by Arkana Laboratories and KDIGO. KDIGO.org/guidelines/gd/ #KDIGO #pathology #kidneypath #renal

Today's #eyeSCANdy is an acellular scanning EM showing "craters" at high power on the subepithelial aspect of the glomerular basement membranes from a biopsy with membranous glomerulonephritis. Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath

We are excited to announce a new Arkana publication: High-Fidelity CRISPR-Cas12a-Based APOL1 Genotyping. (Authors: Randy Haun, Chris Larsen, Jon Wilson, Dan Kenan) This research, led by Dr. Haun, developed a new test using CRISPR-Cas12a to quickly and accurately diagnose APOL1

ANSWER: B - Maternal hyperglycemia A reduced nephron number is associated with low birth weight, preterm birth, reduced kidney mass and size, short stature, maternal hyperglycemia, maternal protein malnutrition, and gene polymorphism for PAX2 and RET. References: Luyckx VA,

What happens when Kappa Light Chain Deposition Disease and Membranous Glomerulopathy, NELL1-Positive occur at the same time in a patient's biopsy? Check out the #Collidescope episode below to learn how the two diseases interact: youtube.com/watch?v=hP_zXF… #renal #pathology #pathX

What is your diagnosis? #DiagnoseThis #pathology #renal #kidneypath

#NeuroNotes Patient is 68 year old woman who presented with progressive proximal weakness since August and severe x2 weeks. - Past medical history included: hyperthyroidism, hyperlipidemia, herpes simplex, hypertension. - Medications included: statin (discontinued 5 days before

The renal biopsy image shows features characteristic of acute pyelonephritis. There is a neutrophil-rich interstitial inflammatory infiltrate and evidence of acute tubular injury. Some tubular lumens are filled with neutrophils (arrow), and in some areas, neutrophils encircle the

Today's #eyeSCANdy shows intestinal giardia. Photo courtesy of Dr. Stephen Bonsib. #renal #pathology