Ion-mediated condensation controls the mechanics of mitotic chromosomes | Nature Materials nature.com/articles/s4156…

Preprint from our #optogenetics team: novel photoswitch that allows an up to 400-fold induction of target gene expression by blue light! Perfectly suited to express biotherapeutics! Great collaboration Institute of Innate Immunity Möglich Lab #ningaloobiosystems biorxiv.org/cgi/content/sh…

Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

Published in Science Magazine: "Direct optical measurement of intramolecular distances with angstrom precision" (Sahl et al.) science.org/doi/10.1126/sc… MPI for Multidisciplinary Sciences Max Planck Institute for Medical Research #Optics #Imaging #Microscopy #MINFLUX #Fluorescence

Einstein's Arne, Ph.D., spoke to We Will Cure on the race to find a treatment for patients with genetic neurological disorders known as KAND. The professor of biochemistry shared how a 2022 XSeed Award helped him understand more about KAND. More at bit.ly/40vzMvn.

You can find me on Bluesky Arne.bsky.social

Single-molecule protein sequencing with nanopores! That's our latest #CDlab paper, now in Nature Reviews Bioengineering Nature Reviews Bioengineering: nature.com/articles/s4422… Here Justas Ritmejeris. Xiuqi Chen and myself provide an overview, with emphasis on the many recent developments.

We are excited to announce the first Salamanca Biophysics Summer Course organized by Carlos Bustamante (The Bustamante Lab) and Eva Nogales (The Nogales Lab ). See the flyer below and consider applying!

Among the most amazing gifts of academia are the friends we make and cherish over the years! Thanks Sobhan Sen for being a generous & knowledgeable guide in 🇮🇳! #Thanksgiving also to incredible friends Pressé Lab Arne & Yale Goldman

Congratulations, Sobhan!!! Well deserved!

smCamera: all-in-one software package for single-molecule data acquisition and data analysis | Journal of the Korean Physical Society link.springer.com/article/10.100…

Our latest work is out in nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…

Trick bacteria with light! It took us a very long time to publish this work, but perseverance and teamwork prevailed. @ Ryan McQuillen Xinxing Yang @ Amilcar Perez @Malcolm Winkler @ Erin Goley @ Kumaran Ramamurthi nature.com/articles/s4146…

Excited to share our latest work on bioRxiv! After years of effort, we reveal how the dynein-dynactin-BicD (DDB) complex adapts to increasing loads: by recruiting a third dynein via an auxiliary BicD adaptor binding its light intermediate chain. Ever wondered why the DDR complex

Yes, as expected, Kinesin-3 KIF1A predominantly adopts a two-heads-bound state, both at saturating and limiting ATP concentrations. This contrasts with Kinesin-1 KIF5B and provides a mechanistic explanation for KIF1A's superprocessivity. Check out the details in our latest

Geometry-based kinetic simulation of DNA-AuNP motor. nature.com/articles/s4146…

My lab at Brown University is hiring a postdoctoral fellow! We develop single-molecule imaging technologies to dissect the spatial regulation of gene expression. For more information about my lab, visit weihan-li.com Please help spread the word! #RNA #imaging

1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! biorxiv.org/content/10.110…

I am extremely proud to see our work about Hepatitis B now published in Cell. From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 cell.com/cell/fulltext/…

Spotlight in Journal of Cell Biology from Bhattacharyya and Klumpp: Combining two powerful imaging techniques, Renganathan et al. (hubs.la/Q03ckMSG0) provide unprecedented detail of the intermediate filament network in cells. hubs.la/Q03ck_TW0 #Cytoskeleton #Vimentin