In the latest issues of Science, Science Translational Medicine, and Science Advances, the #PsychENCODE Consortium lay out findings based on examining human brains at the single-cell level. scim.ag/73Y (THREAD 🧵) #DecodingTheBrain

Did you know some patients w epilepsy can develop Parkinson's - and then their seizures can disappear? New work by Frederic Schaper Center For Brain Circuit Therapeutics unravels this mystery using brain lesions that cause these two disorders academic.oup.com/braincomms/art…

Super cool new work by Frederic Schaper & Michael Fox - creative new use case of lesion network mapping!

Very proud of my lab McLean Hospital Harvard Medical School Broad Institute & our collaborators that @NIHDirector highlighted our recent work published Science Magazine on the molecular basis of #PTSD & #depression. Very committed to finding #targets #biomarkers! directorsblog.nih.gov/2024/06/13/ins…

Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood 👉"The interplay between genetic susceptibility and stress... contributes to the pathogenesis of stress-related disorders and their progression" science.org/doi/10.1126/sc… | SysBioStress - Daskalakis Lab

Interesting paper from Frederic Schaper Michael Fox & Center For Brain Circuit Therapeutics Brigham and Women's Neurology indicating that brain lesions causing parkinsonism versus seizures map to opposite brain networks, providing neuroanatomical insight into conflicting epidemiological evidence academic.oup.com/braincomms/art…

Perivascular spaces ☄️⭕️ in the basal ganglia seem to enlarge more around arteries than veins. We show this using high-resolution QSM, ToF-angiography, and pathology 🧐 Jan Oltmer JCBFM - check it out :) 👇 doi.org/10.1177/027167…

Thank you so much Erik Middlebrooks, MD for the invitation! 🙏I had a great time discussing #epilepsy network mapping and sharing the session with Susie Huang Vince Kumar, MD Gabriel Ramos Llordén, highlighting the beautiful #connectome 2.0 🧠🧑‍🎨 #ASFNR24 American Society of Functional Neuroradiology

Uncovering Plaque-Glia Niches in Human Alzheimer's Disease Brains Using Spatial Transcriptomics biorxiv.org/cgi/content/sh… #biorxiv_genomic

Uncovering Plaque-Glia Niches in Human Alzheimer's Disease Brains Using Spatial Transcriptomics biorxiv.org/content/10.110…

☀️Amazing opportunity for folks looking for a PhD position 🧠

Out Nature Neuroscience: Network localization of brain stim targets for PTSD. TLDR: Lesions connected to this circuit REDUCE risk of PTSD in Vets. Also tested with fMRI and TMS. Free link: rdcu.be/dUVTY With Michael Fox Noah S Philip MD David Carreon MD Amanda Arulpragasam Morey Lab

Excited to see our paper comparing brain networks for #Parkinson and #Epilepsy derived from brain lesions on the cover of @BrainComms! Below a 🧵 Paper: academic.oup.com/braincomms/art…

On my way to #ACNP! Excited to chair a Monday morning panel on molecular dissection of #stress pathways in neuropsychiatric disorders with esteemed colleagues from around the #globe Joel Kleinman Corina Nagy Natalie Matosin and Cristiana Cruceanu !

Hi #ACNP2024, this is my 11th meeting! We are applying Systems Biology approaches on stress-related disorders McLean Hospital Harvard Medical School. Check out my talk on Monday 9:30 am, Poster T69 by Cameron Pernia (Travel Awardee) & Poster T130 by Artemis Iatrou (1st time Attendee) 😀

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in Nature Communications we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s4146… A 🧵 below: