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Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.

Our paper on how X chromosome alterations drive sex differences in translocation renal cell carcinoma is now out in print Cell! Link to explainer thread if you missed it 👉: x.com/srviswanathan/…

Excited to share: "Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap", just published in Nature Biotechnology. Spearheaded by Jiacheng Gu, and powered by everyone in the Gaublomme Laboratory at Columbia Biological Sciences and collaborators. tinyurl.com/4zx95v3a

We are grateful for the invaluable support from the Colorectal Cancer Alliance in our research focused on targeting cancer-associated fibroblasts in colorectal cancer. #ColonCancer #Research #CAF Bassel El-Rayes, MD Colorectal Cancer Alliance IU School of Medicine colorectalcancer.org/article/projec…

Thank you Colorectal Cancer Alliance for supporting our work ! Bassel El-Rayes, MD IU Simon Comprehensive Cancer Center IU School of Medicine

Great end to 2024 publishing this study which is a collaboration between UAB, Emory and Indiana University

We were just notified all NIH nickCTEP_ClinRes @NCI meetings are now CANCELLED. Investigators PLS continue your hard work and dedication to make a difference. #Cancer is indifferent to politics and impacts everyone. @asco #ASCOGI25 #CancerResearch science.org/content/articl…

Cellpose3: one-click image restoration for improved cellular segmentation Carsen Stringer & Marius Pachitariu nature.com/articles/s4159…

Science’s secret weapon is that it cannot be subject to authority. There is no hierarchy when making discoveries which only happens when scientists treat each other as intellectual peers. #standupforscience

“We have now incorporated all of the reviewer feedback…”

🧵 The Myth of Push-Button Bioinformatics 1/ Some think bioinformatics is just pressing a button: 🔘 RNA-seq Analysis 🔘 Make Fancy Figures 🔘 Submit to GenBank If only it were that easy... but reality is very different.

I am super excited to share that my postdoc paper has been published in Nature!! nature.com/articles/s4158…

📢 Join myself, Sebastian and Andreana N. Holowatyj at #ASCO25 for a deep dive into the evolving landscape of #CRC care. 🔬 Biomarker-driven tx in mCRC 🧬 Neoadjuvant strategies in localized disease 📈 The rise of early-onset CRC #crcsm #EOCRC #ASCO25

The FY26 HHS Budget in Brief has been released. It outlines how the existing NIH institutes & centers will be combined into eight (with only NCI, NIA & NIAID retaining their original structure). There are 40% cuts proposed in NIH budget (including the NCI). 😢 Cancer Research 📉

The most practice changing trial from #ASCO25 is now live on NEJM .If this was a drug, this would be approved today. Globally relevant and low-cost intervention that is not only delaying relapse but actually improving survival. Perfect case example of a #cancergroundshot trial.

Time to simply say: Thank you ! A special shout out goes out to: Changli Wei Mehmet Altintas Sanja Sever Salim Hayek ⁦Salim S. Hayek, MD⁩ ⁦International Society of Glomerular Disease⁩ ⁦UTMB Health⁩ ⁦American Society of Nephrology⁩ ⁦Int Society of Nephrology⁩ ⁦Tobias B. Huber⁩

A 2024 study found that ants best humans at tests of collective intelligence. Learn more during #InsectWeek: scim.ag/41ZVpVc News from Science

🎙️ Exciting news! The inaugural episode of the PancChat Podcast is here: “The Role of Advocacy in Educating the Pancreatic Cancer Community." Tune in now: 🔗 spoti.fi/4lx5qQe

STAMP brings us non-destructive single-cell profiling without the sequencing omic.ly/stamp-brings-u…

The dark side of radiotherapy: Cancer Cell cell.com/cancer-cell/ab…