🔥🔥🔥Thanks @cyril_hanus this was a wild ride! congrats to all co-authors, amazing support from Malopolska Centre of Biotechnology UJ, Max Planck Institute of Biophysics, Hummer Lab #DioscuriCentres. Definitely #glycotime!

Sugar coating of membrane proteins has been the Emperor’s New Clothes for structural biologists due to the intrinsic dynamics. Kudos to team Matt Sikora @cyril_hanus we now have GlycoSHIELD sciencedirect.com/science/articl… in Cell to aid visualization of glycans

Live music affects the brain differently than recorded music, according to a study. Live piano performance elicited stronger activity in the amygdala and in a broader neural network for emotion processing than recordings of the same pieces. In PNAS: ow.ly/gtut50QJVpg

Chronicle of GlycoSHIELD in German :) Zelloberfläche: Wechselwirkungen lassen sich einfacher simulieren deutschlandfunk.de/zelloberflaech… @cyril_hanus Matt Sikora IBC Academia Sinica 中央研究院 Academia Sinica

🔬Publication - by danny hsu Khoo KH Cell By using glycoSHIELD, a #reductionist method that reveals the structure of ensembles of #glycans, the impact of glycans on the conformation and activity of complex #glycoproteins are demonstrated. doi.org/10.1016/j.cell…

🔬Publication - by danny hsu Journal of Biological Chemistry This study reveals the structure and interaction of #ZFAND1 and #p97, providing a better understanding of the clearance of #arsenite-induced #stress granule. doi.org/10.1016/j.jbc.… #biochemistry #zincfinger

CryoEM workshop at 中央研究院 Academia Sinica by K-P Wu from IBC Academia Sinica 100 participants for a whole day of ultra-cool stuff.

AI systems capable of #protein structure prediction and protein drug design won #NobelPrize2024 Prize in Chemistry. IBC professors Dr. Kuen-Phon Wu and Dr. Shang-Te Danny Hsu commented in an online interview. See the following link for more details: smctw.tw/17785/

Check out our latest invited review published in Frontiers Biophysics explaining why dynamics in deubiquitinase (DUBs) enzymes matter more than their static structures for function and pathological consequences. Check doi.org/10.3389/frbis.… with danny hsu

Happy to share our work on conformational states of amyloidogenic light chains published as preprint in eLife doi.org/10.7554/eLife.… Thanks to reviewers for doing great job. We will revise soon to make paper more impactful 💪 carlo camilloni Stefano Ricagno danny hsu

The 2024 Franco-Taiwanese Scientific Grand Prize was presented to Danny Shang-te Hsu, deputy director of the Institute of Biological Chemistry at Taipei City-based Academia Sinica, and Cyril Hanus, research fellow at the Institute of Psychiatry and Neuroscience of Paris in Taipei

Good start of year 2025 with the last publication from my postdoc work where we dissected the role of individual domains in amyloidogenic behavior and soluble toxicity of a light chain associated with AL amyloidosis recently accepted in Journal of Molecular Biology 10.1016/j.jmb.2025.168958

IPMB Academia Sinica (中研院植微所) summer undergraduate internship program is now open for applications! 🔗 Apply here: internship.ipmb.sinica.edu.tw/program 📆 Deadline: April 30, 2025

We are thrilled to welcome Makoto Shirakawa joining IPMB Academia Sinica (中研院植微所) as a new PI in this fall. Look forward to exciting research expanding our plant development groups

We used cryoEM and mass spectrometry glycoproteomics plus GlycoSHIELD to determine the molecular structure of human coronavirus 229E spike protein in complex with its human receptor, hAPN in a 6:2 binding stoichiometry. doi.org/10.1038/s41467…

Combining SAXS, MD simulations and HDX-MS, we identified a new conformational (H) state in AL LCs. This state could be a better target of LC stabilizers. In eLife - the journal: A conformational fingerprint for amyloidogenic light chains doi.org/10.7554/eLife.… Stefano Ricagno danny hsu

Very pleased to know that our recent work on hCoV-229E S:hAPN recognition has been highlighted by Nature Communications alongside the work of the newly minted Nobel Prize laureate David Baker lnkd.in/gUwr4bqZ