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Tomorrow marks day 1 of the Schafer Lab at Vrije Universiteit Amsterdam (inactief)! Very excited for this next chapter to unfold!

Wonderful work out of our collaboration with @tesmer_john and Qiuyan Chen. Specific GRK barcodes and arrestin engagement with an atypical GPCR! Check out the new pre-print!

Dear Science Twitter: I recently relocated to the Netherlands and am on the hunt for my next Scientific Adventure👩‍🔬 If you know of a lab in need of a molecular biologist, virologist, or immunologist, please point them my way! I bring experience, innovative, and terrible puns🤦‍♀️

Canonical-atypical GPCR cross talk! CXCR4 mediates ACKR3 through GRK2 phosphorylation. The latest of installment of the Tesmer @tesmer_john - Handel collaboration is now out! molpharm.aspetjournals.org/content/early/…

The October 2023 Highlighted Trainee Author for #MolPharmJournal is Christopher Schafer. His work focuses on resolving the mechanisms of chemokine receptor activation by studying the structure and function of canonical and atypical receptors. Read it here: bit.ly/3RSNzre

Excited to share the latest preprint from my postdoc in the Handel lab. Activation differences between a canonical and atypical GPCR revealed by single-molecule FRET! biorxiv.org/content/10.110…

Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics biorxiv.org/cgi/content/sh… #bioRxiv

CCR9 signal termination is governed by an arrestin-independent phosphorylation mechanism biorxiv.org/cgi/content/sh… #biorxiv_biochem

Non-canonical regulation of canonical GPCR signaling. CCR9 should be an effective activator of G proteins, but is instead suppressed by a unique phosphorylation mechanism. Congrats to Thomas Lamme's first paper of his PhD! biorxiv.org/content/10.110…

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies biorxiv.org/cgi/content/sh… #biorxiv_biochem

It's submission season in Amsterdam! More work cool atypical GPCR work from our group! Newly minted PhD Claudia Perez Almeria details the constitutive activity of ACKR3 using inverse agonistic nanobodies. biorxiv.org/content/10.110…

Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms biorxiv.org/cgi/content/sh… #biorxiv_biochem

The first publication from Thomas Lamme's PhD (and first from the Schafer group)! CCR9 signal termination is arrestin-independent, but governed by GRK phosphorylation. The receptor C-terminus directly contributes to productive G protein coupling. jbc.org/article/S0021-…

Pleased to announce the publication of our conformational analysis of the chemokine receptors CXCR4 and ACKR3 at the single-molecule level! elifesciences.org/articles/100098