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🆕️✨️✨️ Review article Jon Salmanton-García Oliver Cornely Questioning the 14-day dogma in candidemia treatment duration No interventional trials or prospective observational studies assessing shorter durations of candidemia were found Cc Brad Spellberg onlinelibrary.wiley.com/doi/10.1111/my…

🔥🆕PERFECT RCT Preoperatively started antibiotic treatment did not decrease the risk of appendiceal perforation when appendectomy was performed within 24h in adult patients with presumed uncomplicated acute appendicitis. #IDXposts A new standard of care? jamanetwork.com/journals/jamas…

Excellent correspondence Aurélien Dinh Brad Spellberg The Lancet Infectious Diseases The authors suggest that traditional 6–12 months duration of antifungal treatment in pjis caused by Candida spp must be revisited in light of the most comprehensive data currently available thelancet.com/journals/lanin…

Dalicath 127 eme inclusion ! Merci pitié Bleibtreu Alexandre !

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🆕💫Nationwide retrospective cohort study Among the 471 694 eligible patients, 63.3% received 2 g/day and 36.7% received 1 g/day of ceftriaxone. Outcomes of ceftriaxone 2 g versus 1 g daily in hospitalized patients with pneumonia #idxposts academic.oup.com/jac/advance-ar…

🆕💫 Cohort study of 11 073 patients hospitalized with influenza, oseltamivir treatment was associated with a lower in-hospital mortality risk, earlier discharge, and lower readmission rate Todd C. Lee #IDXposts jamanetwork.com/journals/jaman…

🆕💫Antibiotic-related dysbiosis of gut microbiota in healthy volunteers: a comparative study of ceftazidime-avibactam, piperacillin-tazobactam, and ceftriaxone Surprisingly, ceftriaxone exhibiting the most prolonged effects on gut microbiota #IDXposts link.springer.com/article/10.100…

🆕💫Open label Randomized Controlled Trial Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection #IDXposts acpjournals.org/doi/10.7326/AN…

🆕💫Modelling Analysis It's estimated that 2.28 million kg of penicillins and 676,000 kg of cephalosporins (the two most prescribed antibiotic classes), respectively, were required to treat pneumonia and COPD exacerbations in 2019 across 20 countries😱 ijidonline.com/article/S1201-…

🆕💫Real-world cohort study Clinical management of CDI with FMT In patients with CDI who stabilise on antibiotic pretreatment, extending the pretreatment duration beyond 10 days rather than hastening to FMT leads to higher cure rates. thelancet.com/journals/eclin…

130 inclusions Dalicath ! Merci Hôpital Saint-Louis AP-HP aloui meriem SPILF

🆕💫Systematic review and network meta-analysis Clinical Microbiology and Infection Empiric antibiotic therapy for moderate to severe community-acquired pneumonia. #IDXposts clinicalmicrobiologyandinfection.com/article/S1198-…

🆕💫 RCT Oral Vancomycin for Prevention of Recurrent Clostridioides difficile Infection #IDXposts jamanetwork.com/journals/jaman…

Comparison of ceftolozane/tazobactam and meropenem in treating bloodstream infections caused by extended-spectrum β-lactamase- producing Enterobacterales... 🔺"Newer" or "broader" antibiotics are not "stronger" antibiotics. doi.org/10.1093/jac/dk…

🆕🔥Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial #IDXposts thelancet.com/journals/lanre…

🆕🔥ImpresU RCT Methenamine hippurate as prophylaxis for recurrent urinary tract infections in older women – a triple-blind, randomised, placebo-controlled, phase IV trial #IDXposts #UTIWiki clinicalmicrobiologyandinfection.com/article/S1198-…

🆕💫 Systematic Review and Meta-Analysis Cefepime versus Carbapenem Therapy for the Treatment of Invasive Infections with Inducible Chromosomal AmpC-Producing Enterobacterales #IDXposts academic.oup.com/ofid/article/d…

Another study 2021 POINTER RCT Todd C. Lee Brad Spellberg x.com/ABsteward/stat…

🆕🔥 The MULTI-CAP RCT Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia Brad Spellberg Todd C. Lee #idxposts link.springer.com/article/10.100…