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Bio foundation models are great design and engg tools. But can they help decode the fundamental principles of life? We harnessed a single-cell FM for decoding the long-debated relationship between genome arch. and gene coregulation. It all started with an idle curiosity. 1/

With ButovskyLab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimers disease. Deletion of TIM-3 in microglia enhances phagocytic clearance of toxic amyloid beta. nature.com/articles/s4158…

ButovskyLab The immune checkpoint TIM-3 is targeted for cancer therapy, & we found that it is also a promising therapeutic target for Alzheimer's disease. Very excited to share this study led by Kimitoshi Kimura, Ayshwarya Subramanian @Zhuoran_Yin1 & Ahad Khalilnezhad Gene Lay Institute of Immunology & Inflammation. Now out nature 2/2

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease nature nature.com/articles/s4158…

TIM-3 mediates microglia homeostasis through TGFβ signaling & subverts phagocytic activity to curtail disease-associated microglia and Alzheimer’s disease nature.com/articles/s4158… nature Kuchroo Lab Oleg Butovsky Ayshwarya Subramanian @Zhuoran_Yin1 Ahad Khalilnezhad

Targeted deletion of TIM-3 in microglia enhances phagocytosis, shifts them toward a protective state, and improves cognition in an AD mouse model. Kuchroo Lab Oleg Butovsky Ayshwarya Subramanian Zhuoran Yin Ahad Khalilnezhad Gene Lay Institute of Immunology & Inflammation #Microglia #TIM3 📄 nature.com/articles/s4158…

In new study, Kimitoshi Kimura Ayshwarya Subramanian Ahad Khalilnezhad @Zhuoran_Yin1 Oleg Butovsky Kuchroo Lab, et al. reveal that immune checkpoint molecule Tim-3 plays a critical role in how #Microglia, the brain’s immune cells, respond to #AlzheimersDisease. nature nature.com/articles/s4158…

Excited to see our work now published in Nature 🎉 We mapped nearly all yeast TFs' binding and regulatory targets, uncovering some unexpected findings: Full paper here: nature.com/articles/s4158…

Zero-shot evaluation reveals limitations of single-cell foundation models genomebiology.biomedcentral.com/articles/10.11…

My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdocto…

Exciting research from Kuchroo Lab ButovskyLab Mario Suva Howard L. Weiner, MD teams: #KimitoshiKimura Ayshwarya Subramanian @Zhuoran_Yin1 Ahad Khalilnezhad Danyang He Karen Dixon Xiaokai Ding Masashi Nomura @HuiyuanZhang2 Aamir Suhail, with Aviv regev Carlos Cruchaga Blurton-Jones Lab Samuel A Myers & more

Led by Vijay Kuchroo and Oleg Butovsky, our group just published a paper in Nature showing treatment of Alzheimer’s disease by TIM-3 mediated regulation of microglia: tinyurl.com/5572mfb9. Immunology plays a major role in AD over and above anti-amyloid therapy. Very exciting!

Cell‑free DNA testing has gone from concept to standard of care in heart transplantation! 🔗 GenomeWeb: shorturl.at/KybbI I am proud that our 2014 Science Translational Medicine study helped lay the groundwork 🙌 doi.org/10.1126/scitra… #LiquidBiopsy #ScienceForTheWin 🎯

Outstanding Barbara McClintock Life Sciences Lecture by Michelle Monje🎗️ 🟦 @cornell. And honored to have her as the first official visitor to our newly renovated space, and adding her favorite OPCs to our cell type leaderboard 🧫 🧠

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI