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Out today in JNEUROSCI our new paper on action-outcome learning in humans! A nice combination of behavior, modelling and neuroscience led by Richard Morris. Great to see this work published!! jneurosci.org/content/42/17/…

DecisioNeuroLab x Laura Bradfield lab. Such a cool experience sharing our recent findings at #FENS2022 ! Glad we got to meet such a variety of people in neuroscience. FENS

Super excited to finally share this work that has been several years in the making! Goal-directed action is transiently impaired in an hAPP-J20 mouse model of Alzheimer's disease, and in aging male mice regardless of genotype biorxiv.org/content/10.110…

Very excited to receive a BBRF Young Investigator Grant to study #dopamine, #learning & #reward in #impulsive actions. Massive thank you to DecisioNeuroLab & @unswscience Psychology for their support! And to all the volunteers & donors that make BBRFoundation funding possible 🙏

Four years condensed into 189 pages. What a ride. Big thanks to everyone that came along for it 📄🔬🥼👩🏼‍🔬🧠🐭 UNSW Science

Excited to reveal our new preprint showing that learning deficits induced by degeneration of the thalamostriatal pathway can be reversed by normalising striatal cholinergic interneuron (CIN) activity. Great work led by Serena Becchi and Billy Chiang 1/4 biorxiv.org/content/10.110…

We found that inflammation-induced degeneration of the projection from midline thalamus to dorsomedial striatum attenuated the burst-pause activity of CINs and abolished action-outcome encoding for goal direct action but only when animals tried to update prior learning. 2/4

We could reverse both the cellular and psychological deficits by infusions of the MAO-B inhibitor selegiline, NOT because of its effects on dopamine activity, but because it corrected sodium potassium ATPase activity in CINs. 3/4

Selegiline is often used early in PD to bolster DA activity. We suggest its cholinergic effects may make it a useful treatment for the deficits in learning and memory associated with degeneration of the midline thalamus. 4/4

Our next speaker announcement for #AAMS2022 is Dr Serena Becchi Serena Becchi from UNSW Science and DecisioNeuroLab who will be speaking on striatal mechanisms in decision making. Places are limited, register now (for free!) at newcastle.edu.au/school/biomedi…

An exciting new paper from the lab: Part of Miao Ge's PhD thesis, published in a special issue on Pavlovian-instrumental transfer. Miao provides evidence the BNST plays a novel role in the motivational control of instrumental conditioning! 👇 frontiersin.org/articles/10.33…

A new paper from the lab, led by Tom Burton, examines the motivational bases of Pavlovian, habitual and goal-directed behaviour in a positive valence system. We find this system has a hierarchical structure yet these behavioural functions are independent! doi.org/10.1042/ETLS20…

Our paper is out: Goal-directed action is transiently impaired in a hAPP-J20 mouse model of Alzheimer’s disease eneuro.org/content/early/…. We found some cool things here, which I will summarise in the thread for those interested: 1/9

Paper of the week: excellent opinion piece of C Bernard (Christophe Bernard) in SfN Journals who reminds us that failure to replicate conclusions of other scientists is the normal course of science & discuss reasons why published results often do not replicate pubmed.ncbi.nlm.nih.gov/36746632/

Very pleased to share our GLOBAL OPEN ACCESS paper examining the behavioral and neural determinants of goal-directed action in adolescents and adolescents with OCD. Great work led by Iain Perkes, Rich (Rich Morris) and the team! doi.org/10.1016/j.bpsg…

Our new paper is out describing experiments in which were able to reverse the effects of inflammation in the midline thalamus on cognitive flexibility by normalizing cholinergic function in the striatum. Great work led by Serena Becchi and Billy Chieng. science.org/doi/10.1126/sc…

New paper alert! Our research describing the role of dopamine release in dorsomedial striatum during goal-directed action is out in Cell Reports. A bit of an obstacle race, but this very important work led by Genevra Hart and Tom Burton is out now! doi.org/10.1016/j.celr…

What Role Does Striatal Dopamine Play in Goal-directed Action? Find out in a new review paper from the lab led by Genevra Hart and Tom Burton: doi.org/10.1016/j.neur…

Very pleased to draw your attention to our new paper describing evidence of a disinhibitory pallido-cortical pathway that mediates the cognitive control of goal-directed action. This exciting research was led by Beatrice Leung and Billy Chieng. authors.elsevier.com/a/1jKJi3QW8S6F…