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Excited to share our lab’s latest preprint exploring how mutations and transcriptional cell states cooperate to drive therapeutic resistance in Ph+ B cell acute lymphoblastic leukemia (Ph+ ALL)! (1/14) biorxiv.org/content/10.110…

I am thrilled to announce that I have been appointed the new Director of the Institute for Medical Engineering and Science (IMES) at MIT, effective August 1. I would like to express my sincere gratitude and thanks to Elazer for his incredible leadership over the past 6+ years.

I am thrilled that you are taking on this important responsibility MIT IMES to build bridges across the Institute and with the local ecosystem MIT Science MIT Chemistry Koch Institute at MIT Broad Institute Ragon Institute

Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling. Thanks Xiao Wang for unwavering support; Jennifer for human skin study! biorxiv.org/content/10.110…

Happy to share authors.elsevier.com/sd/article/S10… Cell Press Immunity. CD4 T cells contribute to protection against #TB in a reinfection macaque model by interacting with CD8s to generate an anti-inflammatory granuloma environment. Kudos to first authors Sharie Ganchua and @joshuabromley21

I’m thrilled to announce that I will join the Institute of Artificial Intelligence at the Medical University of Vienna (MedUni Wien), led by Christoph Bock Lab @ CeMM & MedUni Vienna, as a tenure-track assistant professor starting December 2024! Check out our website and open positions ai4biomedicine.org

Congratulations Dr Tamar Wolf, not only for your handsome graduation outfit but also for receiving this week the Kennedy Prize - arguably the top distinction that Weizmann gives to its annual PhD Dissertations.

A collaboration between researchers at Massachusetts Institute of Technology (MIT) and Georgia Tech has revealed a new strategy for enabling immune system mobilization against cancer cells. The produces exactly the type of anti-tumor immunity needed to function as a tumor vaccine. chemistry.mit.edu/chemistry-news…

I am excited to see this collaborative project in print with the Finn group, The Jeremiah Johnson Group, and Shalek Lab to target dendritic cells using a pathway that augments immunity ACS Nano

Scalable, compressed phenotypic screening using pooled perturbations go.nature.com/3ZV58uX

🚀 Excited to share our new publication in Nature Biotechnology! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details tinyurl.com/5f8vjhpp! (1/10)

Our Compressed Screening paper is out! So grateful and honored to have worked with an amazing team of individuals 🙏 ya'll are the best 💯

Ever wished you could zoom in more? @W_Shiwei co-advised by Laura Kiessling and Ed Boyden expands a hydrogel up to 20x original size with brain tissue inside. This tool will enable nanoscale-resolution imaging without laborious iterations. nature.com/articles/s4159…

A scientist who successfully treated her own breast cancer by injecting the tumour with lab-grown viruses has sparked discussion about the ethics of self-experimentation go.nature.com/3NXqzEq

Huge cancer breakthrough! mRNA vaccine (similar to COVID vaccine tech) shows stunning results against pancreatic cancer! 75% of responsive patients STILL cancer-free at 3 yr, normally 80% recur. Could revolutionize treatment for one of deadliest cancers! Funded in part by NIH

Congratulations to Stephanie Yiu, Ankit Basak, Ye Won Cho, Laura Kiessling, Chia-Yu Chen, Alex K. Shalek, David Kim & Sizun Jiang for winning the KI Images People's Choice Award! Their image, "Periodontal Petals", shows how cells organize to maintain oral health.

Thank you! It feels amazing to have our collaborative work on periodontitis being recognized for the KI Images People's Choice Award. Koch Institute at MIT MIT Chemistry MIT IMES Harvard School of Dental Medicine BIDMC Harvard Medical School Shalek Lab Kiessling Group Sizun Jiang

Delighted to see Martins Otikovs' titanic effort to provide a contemporary view on spatiotemporally encoded (SPEN) MRI. Thanks Martins and Zhiyong, both for this effort but foremost for the science and ideas we shared over the last decade. See below for more: