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How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

What keeps cancer cells in check—and can we tame hem? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇 📍 Spatial & multi-omic atlas: biorxiv.org/content/10.110… 📍 Regulatory logic: biorxiv.org/content/10.110…

Truly excellent and important work

Great effort by Omer Ali Bayraktar, Stegle Lab & Moritz Mall labs in unravelling GBM cell state variability and spatial organisation at single-cell multimodal resolution. Happy that we could also contribute to this fantastic study! #Glioblastoma #SingleCell #SpatialOmics

Huge congratulations to Sam Behjati who has been elected as a Fellow of the Academy of Medical Sciences 🎉 Sam’s work is transforming how we diagnose and treat childhood cancers, and the Fellowship reflects his outstanding contributions to the field 🌟 sanger.ac.uk/news_item/sam-…

We are happy to be seeking three post-docs across Edinburgh Napier, Glasgow & UCL in an exciting project to investigate mechanisms linking glial ageing/longevity & neurodegeneration (MRC-funded). Positions advertised, info attached (til end of June) Fiona Kerr Nathan Woodling

I'm honoured to join CRUK Cambridge Institute and Cambridge University as a Junior Group Leader of AI for Cancer. My group will focus on reasoning, multimodality, hypothesis-making, and more to decode disease and health. A few positions are opened — consider applying to outsmart cancer together!

Happy to share our new study from my PhD on the spread of farming across Anatolia and into the Aegean and then into Europe. CompEvo & HumanG Labs science.org/doi/10.1126/sc… 👇🏽