How does #HCMV trigger brain cancer growth? Researchers find that US28—a receptor encoded by the HCMV genome—stimulates the sphingosine-1-phosphate pathway and mechanisms that support the proliferation and survival of #glioblastoma cells. Vrije Universiteit Amsterdam (inactief) scim.ag/3L4

.Maarten Bebelman et al. Zerial Lab show that #hepatocyte apical bulkheads are load-bearing mechanical elements that contribute to the ability of #BileCanaliculi to withstand elevated luminal pressure bit.ly/3kShCB0 In our #Mechanobiology collection: bit.ly/3sMxtF9

Dive into our subgroup "Water Dynamics and Pressure Regulation in Cells and Tissues" at #cellbio2023 #ASCB2023! 🧬Amazing talks given by @ditalialab Romain Rollin Carlotta Mayer Maarten Bebelman Joël Lemière Gram Hansen Lab pm White Lab, and Timothy Mitchison. Room 210B on Sat, Dec 2, 1PM.

Studying #extracellularvesicle biogenesis is awesome. Yet, classical methods require lots of cells. Check out how @MargaridaViola used NanoLuc-tetraspanins to explore EV biogenesis in a challenging cell type: iPSC-derived cardiomyocytes. Excited to be part of this cool project!

Check out our new preprint on the role of apical bulkheads and lumen morphology in #Hepatocyte differentiation during #LiverDevelopment. Thanks Lenka Belicova and all co-authors, inc. Elzbieta Gralinska VingronLab Zerial Lab biorxiv.org/content/10.110…

New #review on "Shaping Epithelial Lumina under Pressure" now published #BiochemSocTrans Portland Press! Matt Bovyn and I review lumen formation mechanics and discuss the emerging role of nonlinear mechanics in the elongation of tubular lumina. doi.org/10.1042/BST202…

Happy to share our mini review in COCEBI written by Mai Dan Nguyen together with Ginny Farias and me. We highlight the exciting emerging role of contacts between the endoplasmic reticulum and membrane-less organelles in protein synthesis and secretion. authors.elsevier.com/sd/article/S09…

It's out!😭🕺First preprint as a PhD at the Farias Lab Ginny Farias where we investigated biosynthetic lysosomal membrane protein trafficking, delivery and interactome with Protein Origin, Trafficking And Targeting to Organelle Mapping (POTATOMap)🥔 biorxiv.org/content/10.110…

📝Title: G protein-coupled receptors: a gateway to targeting oncogenic EVs? 👥Authors: Lotte Di Niro, Amber C. Linders, Thomas Glynn, D. Michiel Pegtel, Marco Siderius, Caitrin Crudden, Martine J. Smit Vrije Universiteit Amsterdam (inactief) 🔗oaepublish.com/articles/evcna… Welcome to read. 🫶 #EVs #Cancers

Online now: Tight junctions control lumen morphology via hydrostatic pressure and junctional tension dlvr.it/TBqHBS

Man-made hinges date back to 1600 BC. ⭐️postdoc Benedikt Kuhn et al. now show that elevator-like #solutecarriers had them long before 🤩 to control conformational space + function! Great collab w Julian Langer lab and Seeger Lab. Out in Nature Communications doi.org/10.1038/s41467…

Very happy that the second paper from my postdoc Zerial Lab MPI-CBG Dresden is now published in Development. Together with co-first author Lenka Belicova and collaborators from VingronLab and Shevchenko Lab, we found that apical lumen morphology influences hepatoblast differentiation.

Check out this paper by @MargaridaViola demonstrating the power of NanoLuc-tetraspanins to study #extracellularvesicle biogenesis in cell models where large-scale cultures are not an option: In this case, iPSC-derived cardiomyocytes. Happy I could contribute to this cool project!

🆕New in #JEV🆕 In this study hiPSC-CMs that express NanoLuc-tetraspanin reporters are produced and the regulatory mechanisms of EV biogenesis in hiPSC-CMs upon MI-associated stressors are detailed. isevjournals.onlinelibrary.wiley.com/doi/epdf/10.10…