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What are the functional roles of 3D genome organization? Our paper in nature led by Prashant Bhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez

🧵Following the assassination attempt against former President Donald Trump, we must ask ourselves questions about the future of our country and what we want for ourselves and our children. 1/10

Open to the entire research community this year:

Genome-wide analyses correlate nuclear speckle proximity with gene expression. We share our minireview discussing possible functional relationships between nuclear speckles and gene expression in both health and disease: authors.elsevier.com/sd/article/S09…

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

nature.com/articles/s4159…

EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..? shorturl.at/vuCIh Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!

Cool!

morningstar.com/news/business-…

Split-pool barcoding serves up an epigenomic smorgasbord | Nature Genetics nature.com/articles/s4158…

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New nature nature.com/articles/s4158… nature.com/articles/d4158…

Happy to share our recent work showing bulk transport of speckle material between nuclear speckles within dynamic, multi-phase, linear connections. Nonrandom interchromatin trafficking through dynamic multiphase speckle connections biorxiv.org/content/10.110…