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Ben Adler Brady Cress Nature Microbiology Very cool and much needed!

Yay! 🔥🦠After 3 yrs of work, the Imachi lab managed to cultivate 2 new Asgard archaea from the closest group to eukaryotes: Flexarchaeum & Margulisarchaeum (in honor of Lynn Margulis) Eukaryotes' closest relatives are internally simple syntrophic archaea biorxiv.org/content/10.110…

My lab’s first preprint! We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages. biorxiv.org/content/10.110… 1/10

Marching into spring with our March issue! 💡Considering microbes in microplastic research 🌍 Climate change and harmful microbes 🧬 CRISPRi-ART for functional genomics 🦀 Gut microbiota and cancer therapy response and much more! Read here: nature.com/nmicrobiol/vol…

Excited to see this shout out from Nature Microbiology about our effort to crack open the field of phage functional genomics! Ben Adler

.Ben Adler (UC Berkeley) et al published CRISPRi-ART for #phage functional genomics, a broad-spectrum phage functional genomics platform. It works for all kinds of phages & has already identified 90+ previously unknown genes important for phage fitness! buff.ly/FOqnC7W

Need to design gram-positive bacteria? Our comprehensive genetic toolkit, SubtiToolKit (STK), can be really useful! Check out our study with J.Caro-Astorga and Tom Ellis published in Trends in Biotechnology. STK is coming soon to Addgene! #SynBio #Biotech 👇 doi.org/10.1016/j.tibt…

Fresh in Nature Biotechnology! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with Chappell Lab & Joff Silberg and incredible students. nature.com/articles/s4158…

Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)

Overall, OMEGA enables precision library construction at scale, with per-gene costs as low as $1.50, and bridges computational protein design with high-throughput experimental validation. Read the paper here: biorxiv.org/content/10.110… #synbio #proteinengineering #OMEGA

Harnessing Diversity Generating Retroelements for in vivo targeted hyper-mutagenesis biorxiv.org/content/10.110… #biorxiv_synbio

I am super excited to share our work uncovering the structure and mechanism of an ATPase-associated reverse transcriptase (RT) involved in prokaryotic antiviral defense, now available as a preprint on bioRxiv!🧬🦠🔬 biorxiv.org/content/10.110… 🧵👇

.Yuping Li (UC San Francisco) and colleagues published a new paper on a bacterial immune system targeting jumbo #phages, showing it disrupts an early phage infection compartment to block replication. buff.ly/GcJz6oO

Viruses known as “jumbo phage” are a new hope against the rising antibacterial infection crisis. Researchers have discovered how jumbo phage are able to infect bacteria so efficiently. They found a compartment that "cloaks" valuable DNA material. go.ucsd.edu/3DPMCvy

In the latest issue! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins dlvr.it/TK21Y8

Talk about timing! Presented our work on how RNA-guided mechanisms evolved at the Immune System of Bacteria symposium Institut Pasteur, since 1887—on the same day our Cell paper dropped!

did the FDA just... put the virtual cell timeline at 3 years fda.gov/media/186092/d…

Release 10-RS226 (16th April 2025) GTDB - Genome Taxonomy Database gtdb.ecogenomic.org

New OA Letter: "Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis" rdcu.be/eiJVL ...engineered the tobacco rattle virus to express the RNA-guided TnpB enzyme ISYmu1 and guide RNA for transgene-free germline editing.

Excited to share our latest work on unraveling the role of a key metabolic pathway in human gut microbiome assembly and health-relevant metabolites—powered by machine learning! Led by the talented Yiyi Liu sciencedirect.com/science/articl…