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In the latest issue! Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity dlvr.it/SrttFW

New review from Maelfait IRC - VIB/UGent & Rehwinkel RDM Oxford: ZBP1 is an innate immune sensor for double-stranded nucleic acids adopting the Z conformation. Z-RNA/DNA is generated during viral infections and in autoinflammation and cancer. bit.ly/3JWGwZU

cGAS–STING drives ageing-related inflammation and neurodegeneration. Great paper nature nature.com/articles/s4158…

“The reason I went to medical school [was] to help other people with skin diseases.” —Dr. Emma Guttman-Yassky Learn more: bit.ly/DrGuttmanDayin… For an appointment call 212-241-9728 or email [email protected] #EczemaAwarenessMonth

Great #immunology presented by Benjamin Klein, MD from Michelle Kahlenberg at #ACR23 on the role of Z-DNA in keratinocytes and the perpetuation of type I #interferon inflammation in cutaneous #inflammation of #lupus patients. #sle #rheumatology #dermatology #autoimmunity

Honored that I had a talk at #ACR2023 about my project investigating #autoimmune #photosensitivity in #lupus and #dermatomyositis And thanks to my amazing mentor Michelle Kahlenberg

🚨 Exclusive RED #ALERT on CAR-T cells (click below for more) ⬇️ The U.S. FDA has received reports of T-cell malignancies 🚨 including CAR-positive #lymphoma, in patients who received treatment with BCMA- or CD19-directed #CART cell immunotherapies fda.gov/vaccines-blood…

Our previous analysis of pDCs published in Nature Communications showed that pDCs do not contribute to type I #interferon production in #SLE but they are immunologically exhausted. New work Journal of Investigative Dermatology from V Werth’s group confirmed our data in cutaneous #lupus! sciencedirect.com/science/articl…

Cool preprint showing that ZBP1 works in concert with cGAS to sense Z-form mtDNA and drive IFN-I in autoimmune photosensitivity. Great to see overlap with our recent work. Congrats to the research team! biorxiv.org/content/10.110…

I present new work that we are super proud of. Explains why type I IFNs promote enhanced photosensitivity. Outstanding work by Benjamin Klein, MD and team!!!! Hopefully reviews will go smoothly! 🤞🏻🤞🏻🤞🏻biorxiv.org/content/10.110…

Thanks Michel Gillet for coming to UM for the SBDRC symposium! Excellent talk!

#STTT highlight Nordmann, T. M. et al. Spatial proteomics identifies JAKi as treatment for a lethal skin disease: Klein, B., Kahlenberg, J.M. & Gudjonsson, J.E. Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis. doi.org/10.1038/s41392…

Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis. First author: Andreas Boldt; corresponding author: Benjamin Klein Read the article here: doi.org/10.1111/all.16… The Janus kinase (JAK) signal transducer and

Science #Immunology's March issue is out! This month's cover highlights the mechanisms underlying autoimmune #photosensitivity. UV-damaged mitochondria release #ZDNA into the cytoplasm and trigger inflammatory signaling. Read about this research and more: scim.ag/3F7EgPX

ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation science.org/doi/10.1126/sc… Science Immunology Benjamin Klein, MD Michelle Kahlenberg

#InterferonFriendOrFoe?! Benjamin Klein, MD Michelle Kahlenberg &co show Science Immunology that UV drives Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upreg ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus! science.org/doi/10.1126/sc…

New research suggests that mitochondrial Z-DNA and Z-DNA binding protein drive UV-induced photosensitivity in #lupus and #dermatomyositis. Michelle Kahlenberg Benjamin Klein, MD scim.ag/3F58Nhf

Dr. Benjamin Klein Benjamin Klein, MD & the Michelle Kahlenberg identify key regulators & potential treatment targets in photosensitivity, representing an important step in understanding how to better protect the skin from harmful lesions caused by UV irradiation. medschool.umich.edu/health-lab/dec…