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In a cohort of 51,170 South Asians, #PolygenicRiskScores identified genetic susceptibility to insulin deficiency and fat distribution as key factors in young onset #Type2Diabetes and its rapid complications. #DiabetesPrevention #ChronicDiseases nature.com/articles/s4159…

This is great news (COI: I am a long established consultant and shareholder to Oxford Nanopore) - epigenetic information on long reads at scale! (bonus - also excellent SV resolution coming our way). Haplotype methyl+hydroxymethyl resolution. 50,000 and then hopefully the full 500,000.

One of the strongest risk loci for SLE lies on the MHC region. Earlier work by Steve McCarroll's group (Kamitaki et al Nature 2020; nature.com/articles/s4158…) used African ancestry samples to break down the LD between HLA and Complement gene variants and showed that the risk locus

Please RT! This was such an enjoyable event last year. Registration now open. Free registration for early careers researchers and clinicians in training who submit an abstract

Calling all medical students…

"GWAS of Extended Prescription Analgesic Use Identifies Novel Genetic Loci in Chronic Pain" medrxiv.org/content/10.110…

GxDrug interactions now published at cell genomics :) Michal Sadowski did a ton of great work in this paper. We hope the approach is a step toward improving predictions for individual-specific treatment response

📢Please, RT: do you need to run GWAS, their imputation/meta-analyses/follow-up, PRS & MR? Apply for Short online live course "Introduction to GWAS" by Dec 20, 2024 tinyurl.com/y582m6ud 12th edition, over 530 scientists trained thus far! European Society of Human Genetics (ESHG) supports fellowships

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Tandem repeats (TR) are usually underxeplored in genetic studies🧬 Here, a PheWAS of TRs in UK Biobank 👉N=168,554 👉47 TRs show significant associations with 73 traits 📜paper: nature.com/articles/s4146…

Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) Regeneron Genetics Center for meta-analysis of gene-based tests using summary statistics rgcgithub.github.io/remeta/ This is great work from Tyler Joseph. Pre-print is here​ medrxiv.org/content/10.110…

The newest Regeneron Genetics Center method, REMETA, from Tyler Joseph, Jonathan Marchini, and co. is a game changer - enabling the ability to reconstruct gene-based test associations from single variant summary statistics (and LD).

✅ The UKB-RAP Transition Credits Programme is now open! Thanks to Wellcome, researchers can apply for £1,000 credits to help cover costs of using our data, with enhanced support available. Apply now & accelerate your research! More info: ow.ly/EHSs50Uq2qy

Looking for new post doc role in 2026? 3 year contract working on proteomic data for AD and PD in Oxford. Do get in touch with any questions - would love to hear from you.

There is discrepancy between self-reported and objectively assessed cognitive functioning in #MultipleSclerosis, suggesting we shall use networks of PROMs and cognitive domains. Study from Maureen van Dam MS Centrum Amsterdam Amsterdam UMC Leiden University ▶️ journals.sagepub.com/doi/full/10.11…

Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform research into new medical tests, drugs and treatments. Discover more: ukbiobank.ac.uk/learn-more-abo…

Congrats Alvar Paris Great to see this out

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New nature nature.com/articles/s4158… nature.com/articles/d4158…