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Check out fascinating new work from PCGI leadership Ben Black and Mike Lampson on the role of sequence dependent satellite DNA shape and packaging in female meiosis. nature.com/articles/s4158…

The lab retreat with my research group was filled with inspiring and fun moments, becoming a treasured memory in my decade-long rich experience ⁦Indian Association for the Cultivation of Science⁩. Enjoyed my journey. 😊

We are hiring a young postdoc to work on genome instability, topoisomerase I and transcription with a genome-wide approach. Experience with bioinformatics and/or advanced methods in the field is a plus. If interested, please contact me.

For the post lunch session, we had 3 outstanding talks. Mahak Sharma spoke on a very cool host-pathogen interaction study from her lab, Indranil Banerjee spoke about endosomal sorting during viral infections & BENU BRATA DAS (BBD Lab) spoke about novel mechanisms during DNA damage !

This group I love...Amit Tuli Rohan Khadilkar Lipi Thukral Ahuja Lab Mahak Sharma Ravi Manjithaya Anirban Banerjee Rajender Motiani BENU BRATA DAS (BBD Lab) Indranil Banerjee Sandhya Ganesan sheetalgandotra Tamminenilab Nitin Mohan special thanks to Sriram Varahan for all the help. See u soon..

It was an absolute pleasure to visit the Department of Zoology at Burdwan University, my alma mater, and deliver an invited talk. Thanks to Dr. Sumit Hira, a passionate and brilliant faculty member, for the invitation. I enjoyed the day.⁦DSTIndia⁩ ⁦Indian Association for the Cultivation of Science⁩

Looking forward for the exciting EMBO Workshop 2025: DNA Topology and Topoisomerases in Genome Dynamics (15–19 Sept, SzklarskaPoreba,Poland).⁦⁦. ⁦DSTIndia⁩ Indian Association for the Cultivation of Science⁩⁦Department of Biotechnology⁩ meetings.embo.org/event/25-dna-t…

It was a privilege to visit the Kusuma School of Biological Sciences, IIT Delhi, and deliver an invited talk. I thanks Dr. Saran Kumar for the kind invitation and for the engaging discussions . I truly enjoyed the enriching discussions. ⁦DSTIndia⁩ ⁦Indian Association for the Cultivation of Science⁩

The third #finalist is Srijita Paul Chowdhuri for her paper "TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes."

Feeling happy and proud of my graduate student, @Srijita Palchowdhuri, for winning the 3 rd top finalist award of the The TNQ Distinguished Lectures Inspiring Science Award for her outstanding work published in The EMBO Journal . Many Congratulations Srijita Paul Chowdhuri ! DSTIndia Department of Biotechnology Indian Association for the Cultivation of Science

Our recent work in NAR shows a 20-mer peptide can augment DNA damage response by acting as ATM agonist, potentially preventing neoplastic transformation. Great work done by Ritu Agrawal, collaboration with Avinash Bajaj BRIC - National Institute of Biomedical Genomics Department of Biotechnology BRIC-NII 10.1093/nar/gkaf106

Happy to present our work in The EMBO Journal where we show how p53 acts as a transcriptional repressor by directly recruiting DREAM complex in p21-independent manner. Congrats to Ritu Agrawal pubmed.ncbi.nlm.nih.gov/40038454/. Department of Biotechnology BRIC - National Institute of Biomedical Genomics BRIC-NII

Looking forward to the upcoming 'CDFD Annual Talks-2025'! 🎉 A wonderful opportunity to hear from esteemed invited speakers on cutting-edge research and innovation. #CDFDTalks2025

More metabolism….and now onto DNA repair ⚡️

🚨“Ripping bacteria to shreds” 🚨 VCP/p97, a cellular AAA-ATPase, targets and then using its tweezer like action rips apart bacteria, protecting us from infections. A thread 🦠💥#MolecularMachines #HostDefense #cellularimmunity #microbiology Nature Microbiology

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…

Congratulations Giovanni and team!! Nice work.

Our recent article in Journal of Molecular Biology explores how Post-Translational Modifications (PTMs) orchestrate the repair of trapped Topoisomerase-induced DNA breaks via TDP1 and TDP2. sciencedirect.com/.../pii/S00222… Indian Association for the Cultivation of Science DSTIndia ICMR Department of Biotechnology

Just out in ib journal of Cell Science DISCUSS! Our latest review unravels how mitochondrial topoisomerases safeguard mtDNA, how cells repair mitochondrial damage, and how fission and mitophagy kick in to clear the wreckage—linking it all to human disease. journals.biologists.com/jcs/article-ab…

In their Review, Sangheeta Bhattacharjee and Benu Brata Das BENU BRATA DAS (BBD Lab) discuss the roles of topoisomerases in mtDNA maintenance and repair, and highlight their potential as therapeutic targets. journals.biologists.com/jcs/article/13…